Description of Physical Activity Effect on Neuromuscular Fatigue of Older People

NCT ID: NCT05413590

Last Updated: 2024-09-19

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 93 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-11-30
• Study Completion Date: 2023-06-06

Brief Summary

There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Detailed Description

With advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. Indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. However, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. The aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Conditions

Aging; Fatigue

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Young, Active group

From 18 to 35 years old.

The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:

• at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
• at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
• At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week

Group Type: ACTIVE_COMPARATOR

Questionnaires completion

Intervention Type: OTHER

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Isometric forces

Intervention Type: OTHER

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Energy cost

Intervention Type: OTHER

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Young, sedentary group

From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Group Type: ACTIVE_COMPARATOR

Questionnaires completion

Intervention Type: OTHER

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Isometric forces

Intervention Type: OTHER

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Energy cost

Intervention Type: OTHER

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Old, Active group

From 65 to 80 years old.

The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:

• at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
• at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
• At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week

Group Type: ACTIVE_COMPARATOR

Questionnaires completion

Intervention Type: OTHER

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Isometric forces

Intervention Type: OTHER

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Energy cost

Intervention Type: OTHER

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Old sedentary group

From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Group Type: ACTIVE_COMPARATOR

Questionnaires completion

Intervention Type: OTHER

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Isometric forces

Intervention Type: OTHER

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Energy cost

Intervention Type: OTHER

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Very old, Active group

From 81 years old.

The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count:

• at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR
• at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR
• At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week

Group Type: ACTIVE_COMPARATOR

Questionnaires completion

Intervention Type: OTHER

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Isometric forces

Intervention Type: OTHER

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Energy cost

Intervention Type: OTHER

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Very old sedentary group

From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Group Type: ACTIVE_COMPARATOR

Questionnaires completion

Intervention Type: OTHER

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Isometric forces

Intervention Type: OTHER

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Energy cost

Intervention Type: OTHER

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Interventions

Questionnaires completion

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Intervention Type: OTHER

Isometric forces

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Intervention Type: OTHER

Energy cost

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
• Signed consent for the study obtained
• Subject affiliated or entitled to a social security scheme

Exclusion Criteria

• Pathology or surgical intervention causing a locomotor disorder
• Neurological, cardiovascular or psychological pathology
• Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) > 100 bmp, resting blood pressure > 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
• Mini-Mental State Examination score < 20 (>80 years old)
• Significant change in the amount of physical practice over the last 5 years.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

LEONARD FEASSON, PHD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Saint Etienne

Guillaume MILLET, PhD

Role: STUDY_CHAIR

UNIVERSITE DE SAINT ETIENNE

Locations

Chu de Saint-Etienne

Saint-Etienne, , France

Countries

France

Other Identifiers

ANSM

Identifier Type: OTHER

Identifier Source: secondary_id

21CH033

Identifier Type: -

Identifier Source: org_study_id