Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest

NCT ID: NCT06122337

Last Updated: 2025-02-19

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-10-31
• Study Completion Date: 2026-12-31

Brief Summary

The goal of this observational study is to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients. The main questions it aims to answer are:

• Whether the protocolized classification of cardiac arrest minimizes the proportion of unknown causes and mis-classification in young cardiac arrest patients?
• Whether the incorporation of genetic tests in the identification protocol of arrest cause helps the recognition of sudden arrhythmic death syndrome in young cardiac arrest patients?

Participants will be asked to received serial examinations including genetic analysis to explore the cause of cardiac arrest.

Detailed Description

Out-of-hospital cardiac arrest (OHCA) is an important emergency medical issue. Although the refinement of resuscitation and post-arrest care improved the survival rate of cardiac arrest patients, the rate of survival-to-discharge is still less than 20%. The Utstein templates for cardiac arrest classified the pathogenesis of cardiac arrest into medical (presumed cardiac or unknown, other medical causes); traumatic cause; drug overdose; drowning; electrocution; or asphyxial (external). Presumed cardiac caused arrest in pre-hospital setting might turned out to be other cause after series of workup. In recent observational studies, cardiac origin arrests accounted for about 50% of OHCA. These patients had better prognosis than patients with non-cardiac causes. Identifying and correcting the persistent precipitating pathology is also a crucial element in managing post cardiac arrest syndrome.

Systemic analysis protocol, including history, electrocardiogram, laboratory exam, imaging studies, cardiac catheterization, toxicology screening, could facilitate the identification of the causes of cardiac arrest and minimize the proportion of unknown causes. In young patients, structural heart diseases and arrhythmias were also the important causes of cardiac origin arrest. Genetic tests might aid the recognition of sudden arrhythmic death syndrome in this group. This study aims to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients, and minimized the proportion of unknown causes and mis-classification.

Conditions

Out-Of-Hospital Cardiac Arrest

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• non-traumatic out-of-hospital cardiac arrest

Exclusion Criteria

• traumatic cardiac arrest
• pregnancy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Min-Shan Tsai, MD, PhD

Role: STUDY_DIRECTOR

National Taiwan University Medical College and Hospital

Locations

National Taiwan University Hospital

Taipei, , Taiwan

Site Status: RECRUITING

Countries

Taiwan

Central Contacts

Dean-An Ling, MD

Role: CONTACT

speckle0714@gmail.com

+886-972651091

Min-Shan Tsai, MD, PhD

Role: CONTACT

mshanmshan@gmail.com

Other Identifiers

202303025RINC

Identifier Type: -

Identifier Source: org_study_id