Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study
NCT ID: NCT00500773
Last Updated: 2014-05-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2007-07-31
2008-05-31
Brief Summary
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Detailed Description
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The researchers aim to define the critical role of inflammatory markers and cardiovascular risk factors as a predictor of an increased risk for myocardial and endothelial dysfunction in marathon runners.
The study groups are divided into average trained runners (40 km/week), average trained obese runners and highly trained runners (\> 70km/week). Training programmes are supervised by professional coaches. Individual scientific marathon contests are organized for the assessments.
Diagnostic tools include measurements of pulse wave velocity and heart rate turbulence, echocardiography and, for the first time, MRI-scans pre- and post marathon running. Additionally, cardiovascular markers such as endothelial progenitor cells (EPCs)and adiponectin are measured. Inflammatory markers include c-reactive protein (CRP), interleukins and tumor necrosis factor.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Obese subjects: BMI \> 27 and waist circumference \> 102cm
Exclusion Criteria
* insulin dependent diabetes mellitus
* multiple drug therapy
* GFR \< 60 ml/min.
* claustrophobia
* metal implants
30 Years
60 Years
MALE
Yes
Sponsors
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Ludwig-Maximilians - University of Munich
OTHER
Technical University of Munich
OTHER
Responsible Party
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Lehrstuzl für Praeventive und rehabilitative Sportmedizin
Principal Investigators
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Henner Hanssen, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Prevention and Sportmedicine, Technical University Munich
Locations
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Department of Prevention and Sportsmedicine, Technical University of Munich
Connollystrasse 32, Munich, Bavaria, Germany
Countries
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Related Links
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Institutional homepage
Other Identifiers
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1807/07
Identifier Type: -
Identifier Source: org_study_id
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