Release of Epoxyeicosatrienoic Acids From Erythrocytes During the Use of Extracorporeal Procedures (Heart-lung Machine)
NCT ID: NCT04598360
Last Updated: 2022-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
15 participants
INTERVENTIONAL
2020-11-01
2022-01-01
Brief Summary
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We will determine differences in RBC fatty acids profiling in patients before and after heart-lung-machine intervention. RBC fatty acids profiling will be achieved by using targeted HPLC-MS mass spectrometry.
It is believed that during HLM there is an increase in EETs / DHETs in the serum and in the erythrocytes. It is believed that shear forces play an important role in the release of erythrocyte EETs / DHETs.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Experimental: Erythrocyte Fatty-Acid Status
Erythrocyte Fatty-Acid Status Profiling of cardiac surgery patients are studied before and during heart-lung-machine procedure using LC-MS / MS
Heart-Lung-Machine
blood sample before and during a single Heart-Lung-Machine procedure
Interventions
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Heart-Lung-Machine
blood sample before and during a single Heart-Lung-Machine procedure
Eligibility Criteria
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Inclusion Criteria
* Age over 18 years
* Ability to consent
* There is a written consent of the study participant
Exclusion Criteria
18 Years
85 Years
ALL
No
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Benjamin Gollasch
Benjamin Gollasch
Locations
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Charité University Experimental & Clinical Research Center
Berlin, , Germany
Countries
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Other Identifiers
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EA2/113/08
Identifier Type: -
Identifier Source: org_study_id
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