Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-05-31

Study Completion Date

2007-08-31

Brief Summary

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To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

Detailed Description

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Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

Conditions

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Cardiac Surgery

Keywords

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Cardiac biomarker cardiac surgery elderly postoperative complications Patients aged 75 years or older undergoing cardiac surgery

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion Criteria

* positive cardiac troponin T test within the week before surgery
* patients undergoing emergent procedures
* patients with preoperative mechanical cardiac support
* patients undergoing hemodialysis

Minimum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Stefan W. Suttner, MD

Role: PRINCIPAL_INVESTIGATOR

Klinikum Ludwigshafen

Locations

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Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen

Ludwigshafen, , Germany

Site Status

Countries

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Germany

Other Identifiers

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KliLuNTproBNP

Identifier Type: -

Identifier Source: org_study_id