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Therapeutic Thoracentesis for Patients With Congestive Heart Failure and Large Pleural Effusion

NCT ID: NCT00629538

Last Updated: 2010-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-03-31

Study Completion Date

2009-07-31

Brief Summary

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Transudative pleural effusions are a common manifestation of patients with congestive heart failure. Severe dyspnea and respiratory failure may develop in those with large effusions, which in general show poor response to medical treatment. Therapeutic thoracenteses (TT) may be indicated in these patients and can produce marked relief of symptoms. However, the underlying effect of TT on gas exchange and respiratory mechanics in theses patients remains unclear. The researchers' hypothesis is that,TT may improve arterial oxygenation and respiratory mechanics in patients with congestive heart failure complicated by large pleural effusions.

Detailed Description

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Conditions

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Congestive Heart Failure Transudative Pleural Effusion

Keywords

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congestive heart failure thoracentesis transudative pleural effusions

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Therapeutic thoracentesis

Thoracentesis was performed with drainage of 500 ml of pleural fluid first and every 200 ml thereafter until pleural pressure was lower than -20 cm H2O, chest discomfort developed, or no more pleural fluid could be removed.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* transudative pleural effusion established by the criteria of Light
* the effusion occupying at least half of one hemithorax shown on chest radiography
* symptoms of respiratory distress
* diagnosis of congestive heart failure

Exclusion Criteria

* severe uncontrolled coagulopathy
* unstable hemodynamics
* diagnosis of liver cirrhosis, chronic obstructive pulmonary disease,asthma and/or any parenchymal lung disease, such as pneumonia, fibrosis or malignancy.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taipei Medical University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Taipei Medical University Hospital

Principal Investigators

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Chi-Li Chung, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Internal Medicine, Taipei Medical University Hospital

Locations

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Taipei Medical University Hospital

Taipei, , Taiwan

Site Status

Countries

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Taiwan

References

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Chen WL, Chung CL, Hsiao SH, Chang SC. Pleural space elastance and changes in oxygenation after therapeutic thoracentesis in ventilated patients with heart failure and transudative pleural effusions. Respirology. 2010 Aug;15(6):1001-8. doi: 10.1111/j.1440-1843.2010.01812.x. Epub 2010 Jul 20.

Reference Type DERIVED
PMID: 20646242 (View on PubMed)

Other Identifiers

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TMUHIRB20070304

Identifier Type: -

Identifier Source: org_study_id