Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

104 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-18

Study Completion Date

2024-06-30

Brief Summary

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The goal of this clinical trial is to evaluate the effect of intraoperative terlipressin on the incidence of early postoperative acute kidney injury in deceased doner liver transplantation. Patients were randomly divided into experimental group and control group by numerical randomization table. The experimental group was injected with terlipressin perioperative and the control group was injected with placebo

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Detailed Description

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acute kidney injury is a relatively common complication in patients with liver transplantation. Most centers have established prediction models for acute kidney injury after liver transplantation, but the incidence cannot be reduced through perioperative anesthesia management. As an vasopressin receptor agonist, terlipressin can increase blood pressure and improve kidney perfusion at the same time, and perioperative application may reduce the incidence of postoperative acute kidney injury

Conditions

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Acute Kidney Injury Liver Transplant; Complications

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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experimental group

Continuous terlipressin infusion，Use a syringe to dilute to 50ml Infusion speed is 2ug/kg\*h, From the beginning to the end of the surgery.

Group Type EXPERIMENTAL

Terlipressin

Intervention Type DRUG

The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins

control group

Continuous normal saline infusion，Use a syringe to draw 50ml Infusion speed is 4ml/h, From the beginning to the end of the surgery.

Group Type PLACEBO_COMPARATOR

normal saline

Intervention Type DRUG

The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins

Interventions

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Terlipressin

The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins

Intervention Type DRUG

normal saline

The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins

Intervention Type DRUG

Other Intervention Names

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Glypressin normal sodium

Eligibility Criteria

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Inclusion Criteria

* 1\) Patients who plan to undergo liver transplantation in our hospital 2) Patients or family members sign informed consent

Exclusion Criteria

* Patients \<18 years old;② Patients undergoing autologous liver transplantation or combined transplantation;③ Patients with lower extremity artery stenosis;(4) Patients with severe heart disease、lung disease、kidney disease;⑤ Patients with severe lung disease;⑥ Patients who used renal replacement therapy before surgery;⑦ the depth of one kidney from the body surface is greater than 4cm;⑧ Patients treated with terlipressin within 2 weeks before surgery⑨ Patients allergic to terlipressin.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No