Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

NCT ID: NCT04107883

Last Updated: 2023-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-10-01

Study Completion Date

2024-12-31

Brief Summary

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To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.

Detailed Description

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Conditions

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End Stage Liver DIsease Liver Transplantation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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control group

perform artificial colloidal solution transfusion during anhapetic phase.

Group Type EXPERIMENTAL

blood sample

Intervention Type DIAGNOSTIC_TEST

get blood samples at several specific points in time during perioperation

anhapetic group

Perform plasma transfusion during anhapetic phase.

Group Type EXPERIMENTAL

fresh frozen plasma

Intervention Type BIOLOGICAL

perform plasma transfusion in different phases during perioperation

blood sample

Intervention Type DIAGNOSTIC_TEST

get blood samples at several specific points in time during perioperation

Interventions

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fresh frozen plasma

perform plasma transfusion in different phases during perioperation

Intervention Type BIOLOGICAL

blood sample

get blood samples at several specific points in time during perioperation

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Child A/B cirrhosis
* patients who undergo the first OLT
* Informed and consented
* complete follow-up
* cooperate with treatment

Exclusion Criteria

* re-transplant
* combined liver and other organ transplantation
* BMI≥30Kg/m2
* patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion
* acute liver failure
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Beijing Chao Yang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xun Liu

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anshi Wu

Role: STUDY_CHAIR

Capital Medical University Affiliated Beijing Chaoyang Hospital

Locations

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Capital Medical University Affiliated Beijing Chaoyang Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xun Liu

Role: CONTACT

+86 13466505725

Anshi Wu

Role: CONTACT

+86 010 85231330

Facility Contacts

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Liu Xun

Role: primary

13466505725 ext. +86

Wu A Shi

Role: backup

85231330 ext. +86 010

Other Identifiers

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LX-2019-LT-1

Identifier Type: -

Identifier Source: org_study_id