Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation

NCT ID: NCT06598228

Last Updated: 2024-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

700 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-07-01

Study Completion Date

2024-09-01

Brief Summary

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Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality. The recovery mode of kidney injury after PLT has not been systematically studied. Therefore, in this study the investigators aimed to systematically evaluate prognosis of AKI after PLT, combine the recovery mode of AKI with related risk factors, and establish a relationship between AKI and CKD.

Detailed Description

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Conditions

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Postoperative Acute Kidney Injury Pediatric Liver Transplantation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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the group without acute kidney injury

Patients not diagnosed with acute kidney injury according to KDIGO(Kidney Disease: Improving Global Outcomes) criteria

No Intervention: Observational Cohort

Intervention Type OTHER

no intervention

the group with transient acute kidney injury

Patients diagnosed with acute kidney injury according to KDIGO(Kidney Disease: Improving Global Outcomes) criteria and recovered within 48h

No Intervention: Observational Cohort

Intervention Type OTHER

no intervention

the group with persistent acute kidney injury

Patients diagnosed with acute kidney injury according to KDIGO(Kidney Disease: Improving Global Outcomes) criteria and sustained over 48h

No Intervention: Observational Cohort

Intervention Type OTHER

no intervention

Interventions

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No Intervention: Observational Cohort

no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients who received a liver transplant for the first time.
* Patients who were younger than 18 years of age at the time of transplant.

Exclusion Criteria

* Patients with incomplete clinical data.
* Patients with less than 5 years of follow-up.
* Patients who have combined multiple solid organ transplants.
* Patients with preoperative renal impairment (eGFR\<60ml/min/1.73 m2 or prior renal replacement therapy).
Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tianjin First Central Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wei Gao

Head of the pediatric organ transplant unit

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Tianjin First Central Hospital

Tianjin, , China

Site Status

Countries

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China

Other Identifiers

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20240903-1

Identifier Type: -

Identifier Source: org_study_id

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