Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation
NCT ID: NCT03522688
Last Updated: 2023-07-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
214 participants
INTERVENTIONAL
2017-07-11
2024-07-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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control group
The control group was given normal saline by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour
Normal saline
The control group was given normal saline by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour
treatment group
The treatment group was given dexmedetomidine by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour
Dexmedetomidine
The treatment group was given dexmedetomidine by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour.
Interventions
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Dexmedetomidine
The treatment group was given dexmedetomidine by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour.
Normal saline
The control group was given normal saline by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* dual living donor liver transplantation
* severe cerebral artery disease
* severe cardio-pulmonary disease
20 Years
65 Years
ALL
No
Sponsors
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Asan Medical Center
OTHER
Responsible Party
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Jun-Gol Song
Professor
Principal Investigators
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Jun-Gol Song, PhD
Role: PRINCIPAL_INVESTIGATOR
Asan Medical Center
Locations
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Asan medical center
Seoul, Songpa-gu, South Korea
Countries
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References
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Rimola A, Gavaler JS, Schade RR, el-Lankany S, Starzl TE, Van Thiel DH. Effects of renal impairment on liver transplantation. Gastroenterology. 1987 Jul;93(1):148-56. doi: 10.1016/0016-5085(87)90327-1.
Wyssusek KH, Keys AL, Yung J, Moloney ET, Sivalingam P, Paul SK. Evaluation of perioperative predictors of acute kidney injury post orthotopic liver transplantation. Anaesth Intensive Care. 2015 Nov;43(6):757-63. doi: 10.1177/0310057X1504300614.
Cho JS, Shim JK, Soh S, Kim MK, Kwak YL. Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery. Kidney Int. 2016 Mar;89(3):693-700. doi: 10.1038/ki.2015.306.
Liu Y, Sheng B, Wang S, Lu F, Zhen J, Chen W. Dexmedetomidine prevents acute kidney injury after adult cardiac surgery: a meta-analysis of randomized controlled trials. BMC Anesthesiol. 2018 Jan 15;18(1):7. doi: 10.1186/s12871-018-0472-1.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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DEX-LT
Identifier Type: -
Identifier Source: org_study_id
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