Intraoperative Normal Saline Administration and Acute Kidney Injury in Patients Undergoing Liver Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1440 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-01

Study Completion Date

2022-12-31

Brief Summary

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The investigators attempted to investigate the association of the type of crystalloid administered during liver transplantation with postoperative clinical outcomes. The investigators hypothesized that the greater amount of normal saline or half-saline administered during liver transplantation might be associated with the increased risk of acute kidney injury compared to the balanced crystalloids.

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Detailed Description

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Liver transplantation requires a long operation time and is often associated with a significant amount of surgical bleeding. It is common for the anesthesiologist to infuse large amounts of fluid or blood products due to bleeding, hemodynamic instability, or ascites drainage. Therefore, in the anesthesia for liver transplantation, optimal management of fluid administration is necessary and the choice of the type of crystalloid may affect the prognosis or the incidence of postoperative complications of patients.

The investigators attempted to investigate the association of the type of crystalloid administered during liver transplantation with postoperative clinical outcomes. The investigators hypothesized that the greater amount of normal saline or half-saline administered during liver transplantation might be associated with the increased risk of acute kidney injury compared to the balanced crystalloids.

Conditions

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End Stage Liver DIsease Liver Transplant; Complications Liver Cirrhosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Balanced group

Patients who received balanced crystalloids of lactated Ringer's solution or plasma solution during liver transplantation surgery

Balanced crystalloid solution

Intervention Type DRUG

Patients received balanced crystalloids such as lactated Ringer's solution or Plasma solution as a maintenance crystalloid during liver transplantation surgery.

Saline group

Patients who received only normal saline during liver transplantation surgery

Normal saline

Intervention Type DRUG

Patients received normal saline as a maintenance crystalloid during liver transplantation surgery.

Interventions

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Normal saline

Patients received normal saline as a maintenance crystalloid during liver transplantation surgery.

Intervention Type DRUG

Balanced crystalloid solution

Patients received balanced crystalloids such as lactated Ringer's solution or Plasma solution as a maintenance crystalloid during liver transplantation surgery.

Intervention Type DRUG

Other Intervention Names

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Lactated Ringer's solution Plasma solution

Eligibility Criteria

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Inclusion Criteria

* Consecutive patients who underwent living or deceased donor liver transplantation at our tertiary care university hospital between 2004 and 2018

Exclusion Criteria

* patients with baseline renal dysfunction of hepatorenal syndrome or chronic kidney disease
* missing preoperative serum creatinine value
* missing other baseline or outcome variables
* patients who received retransplantation

Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No