Risk of Acute Kidney Injury in Living Liver Donor Surgery

NCT ID: NCT05255510

Last Updated: 2022-05-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 130 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-10-10
• Study Completion Date: 2021-06-10

Brief Summary

Acute kidney injury (AKI) is one of the most common complication after restricted fluid therapy for major surgery. The aim of this study is to evaluate the incidence of AKI as defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria in living liver donor hepatectomy in which applied intraoperative protocolized fluid restriction targeting a low central venous pressure (CVP) level and high pulse pressure variation (PPV) / systolic pressure variation (SPV).

Detailed Description

Operative blood loss and need for transfusion are risk factors associated with mortality after partial hepatectomy. The low central venous pressure (CVP) anesthetic technique has been strongly advocated to minimize hepatic venous bleeding during hepatectomy. Low CVP technique for living donor hepatectomy may not be advantageous regarding the safety of healthy living donors. Safer, simpler, and more useful fluid management methods are, therefore, required to reduce blood loss and subsequent morbidity during living donor hepatectomy. Pulse pressure variation (PPV) and systolic pressure variation (SPV) are the dynamic parameters of hemodynamic used to access the volume status and fluid responsiveness in mechanically ventilated patients.

Based only on the serum creatinine increase, AKI occurs in 5-15% of hepatectomy patients.In this study, we aimed to evaluate the incidence of AKI based on the change of serum creatinine levels in living liver donor hepatectomy regarding intraoperative fluid restriction targeting low CVP levels and high PPV and SPV depending on our protocolized fluid management.

130 living liver donors were admitted for a retrospective observational study. The low central venous pressure (<5 mmHg) and high pulse pressure variation (PPV<20%) / systolic pressure variation (SPV<15%) were applied to reduce intraoperative blood loss as fluid management until the end of the hepatic parenchymal division. AKI was defined using the KDIGO criteria according to the serum creatinine. The SPSS 11.5 program was used for statistical analysis.

Conditions

Acute Kidney Injury; Liver Transplant; Complications; Fluid and Electrolyte Imbalance

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• patients who underwent living liver donor hepatectomy

Exclusion Criteria

-

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Elvan Onur Kırımker

UNKNOWN

Sponsor Role: collaborator

Sevcan Büyük

UNKNOWN

Sponsor Role: collaborator

Elif Beyza Baskan

UNKNOWN

Sponsor Role: collaborator

Ali Abbas Yılmaz

UNKNOWN

Sponsor Role: collaborator

Deniz Balcı

UNKNOWN

Sponsor Role: collaborator

Kaan Karayalçın

UNKNOWN

Sponsor Role: collaborator

Mustafa Kemal Bayar

UNKNOWN

Sponsor Role: collaborator

Ankara University

OTHER

Sponsor Role: lead

Responsible Party

Süheyla Karadağ Erkoç

Anesthesiology and Reanimation

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Süheyla Karadağ Erkoç

Role: PRINCIPAL_INVESTIGATOR

Ankara University

Locations

Süheyla Karadağ Erkoç

Ankara, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

AnkaraUni

Identifier Type: -

Identifier Source: org_study_id