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Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors

NCT ID: NCT07301853

Last Updated: 2025-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

9999 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-11-24

Study Completion Date

2045-12-31

Brief Summary

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This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors. By collecting comprehensive clinical data and conducting systematic long-term follow-up, the researchers intend to establish a specialized, standardized, and individualized follow-up management system. The ultimate goal is to optimize intervention strategies and improve patient prognosis and quality of life for both recipients and donors.

Detailed Description

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Conditions

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Living Donor Liver Transplantation Recipients Deceased Donor Liver Transplantation Recipients Living Liver Donor

Keywords

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liver transplantation living donors transplant recipients follow-up studies

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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recipients

A patient who received a new, healthy liver (or part of one from a living donor) to replace their own diseased liver

liver transplantation

Intervention Type PROCEDURE

Patients undergo standard liver transplantation according to clinical protocols. Postoperative management and follow-up are conducted per routine standard of care. Clinical data, including survival, adverse events, and quality of life (assessed by questionnaires/scales), are collected observationally at regular follow-up intervals.

living donors

A healthy person who donated a portion of their healthy liver to someone with liver failure.

Living Donor Hepatectomy

Intervention Type PROCEDURE

Living donors undergo standard hepatectomy procedures. Postoperative recovery and long-term health outcomes are monitored through routine follow-up visits and assessments.

Interventions

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liver transplantation

Patients undergo standard liver transplantation according to clinical protocols. Postoperative management and follow-up are conducted per routine standard of care. Clinical data, including survival, adverse events, and quality of life (assessed by questionnaires/scales), are collected observationally at regular follow-up intervals.

Intervention Type PROCEDURE

Living Donor Hepatectomy

Living donors undergo standard hepatectomy procedures. Postoperative recovery and long-term health outcomes are monitored through routine follow-up visits and assessments.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Patients undergoing liver transplantation or living donor hepatectomy at the study center (living donor should be approved by the hospital ethics committee for living organ donation);
2. Age 18 years or older;
3. Willing to participate in the long-term follow-up management program;
4. Signed informed consent form;

Exclusion Criteria

1. Patients undergoing combined organ transplantation
2. Patients with severe mental illness or cognitive impairment who are unable to cooperate with follow-up assessments.
3. Donors whose surgery is aborted intraoperatively for any reason.
4. Unable or unwilling to comply with the long-term follow-up schedule.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mukogawa Women's University

UNKNOWN

Sponsor Role collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wen Fang

Role: PRINCIPAL_INVESTIGATOR

Second Affiliated Hospital, School of Medicine, Zhejiang University

Locations

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The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wen Fang

Role: CONTACT

Phone: 19705094680

Email: [email protected]

Facility Contacts

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Wen Fang

Role: primary

Other Identifiers

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2025-0793

Identifier Type: -

Identifier Source: org_study_id