Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

430 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-21

Study Completion Date

2025-11-30

Brief Summary

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Increased indications for transplantation continue to worsen the shortage of organs and need the extension of graft sampling criteria and the search for new potential sources of organs. Despite undeniable success in the short term, due to major advances in surgery, medicine and research, transplant recipients continue to face the risk of chronic rejection and long-term complications.

The University Hospital Federation "FHU SUPORT" was created to optimize the chances of success of the organ transplant and improve the quality of life of the transplanted patient. FHU SUPORT 's ambition is based on a translational strategy that presents two priority areas:

Axis 1: Optimization, evaluation, conditioning of the donor, graft, recipient Axis 2: Personalized follow-up of the transplanted patient in the short and long term Identifying factors for long-term graft and patient survival through translational research from a common cohort and biological collection will predict transplant rejection, prolong graft function, or improve the patient's care.

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Detailed Description

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Conditions

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Organ Transplantation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

various blood and urine samples will be collected from the recipient at D0, D1, D3, D7, D14, M1, M3, M6 and M12 and intraoperative bile collection ancillary studies : stools at D0 D7 M1 and M3 will be collected for liver transplant patient

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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blood, bile and urine samples

blood and urine samples at D0,D1, D3 D7, D14, M1, M3, M6 and M12

Group Type EXPERIMENTAL

blood and urine samples

Intervention Type OTHER

various blood and urine samples will be collected from the recipient at D0, D7, D14, M1, M3, M6 and M12 and intraoperative bile collection

Interventions

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blood and urine samples

various blood and urine samples will be collected from the recipient at D0, D7, D14, M1, M3, M6 and M12 and intraoperative bile collection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or female over 18 (no age limit)
* affiliated to a social security organization
* Recipient (s) of a kidney, liver or heart transplant
* followed by at least one of the FHU SUPORT centers (Tours, Poitiers, Limoges, Rennes)
* having given informed consent to participate in the cohort.