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Development and Validation of a Clinical Risk Prediction Model for Early Acute Kidney Injury Within 48 Hours After Liver Transplantation

NCT ID: NCT06750770

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

453 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2022-12-15

Brief Summary

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Acute kidney injury (AKI) is a common complication after liver transplantation, with an incidence of 12.7-95%. The occurrence of acute kidney injury after transplantation is related to the poor prognosis of patients, which significantly increases the length of hospital stay, hospitalization costs and mortality of patients. Early recognition of acute kidney injury after transplantation is of great significance. Therefore, by collecting preoperative and intraoperative variables, this study intends to establish and verify a clinical risk prediction model for early AKI after liver transplantation, in order to provide clinicians with a visual prediction tool to identify patients with high risk of early AKI after liver transplantation immediately after the operation, so as to start clinical intervention as soon as possible and improve the prognosis of patients.

Detailed Description

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Conditions

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Acute Kidney Injury Liver Transplantation Model

Keywords

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acute kidney injury, liver transplantation, model, validation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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AKI group

Participants who were diagnosed acute kidney injury(AKI)

KDIGO CRITERIA

Intervention Type DIAGNOSTIC_TEST

2012 KDIGO DIAGNOSTIC CRITERIA

Non-AKI group

Participants who were not diagnosed AKI

KDIGO CRITERIA

Intervention Type DIAGNOSTIC_TEST

2012 KDIGO DIAGNOSTIC CRITERIA

Interventions

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KDIGO CRITERIA

2012 KDIGO DIAGNOSTIC CRITERIA

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* patients who underwent liver transplantation in Beijing Tsinghua Changgung Hospital.

Exclusion Criteria

* (1) under 18 years of age (2) post-renal transplant (3) liver combined with other organ transplants (4) preoperative requirement for renal replacement therapy (RRT) (5) patients with second or multiple liver transplants (6) preoperative estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73m2, and (7) patients with severe illness leading to termination of surgery.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Tsinghua Chang Gung Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Beijing Tsinghua Changgung Hospital

Beijing, Province, China

Site Status

Countries

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China

Other Identifiers

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22216-4-01

Identifier Type: -

Identifier Source: org_study_id