Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2014-12-31

Brief Summary

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To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters. The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is associated with increased solute removal and improved acid-base statues when compared to controls who do not receive CRRT

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Detailed Description

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as above

Conditions

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Acute Kidney Injury Liver Disease Chronic Kidney Disease End Stage Kidney Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Renal replacement therapy

Liver transplant recipients who receive continuous renal replacement therapy intra-operatively.

Group Type EXPERIMENTAL

Renal replacement therapy

Intervention Type PROCEDURE

Liver transplant recipients receiving continuous renal replacement therapy for duration of liver transplant surgery.

No CRRT

This arm consists of standard of care without CRRT in the OR for OLT

Group Type ACTIVE_COMPARATOR

Renal replacement therapy

Intervention Type PROCEDURE

Liver transplant recipients receiving continuous renal replacement therapy for duration of liver transplant surgery.

Interventions

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Renal replacement therapy

Liver transplant recipients receiving continuous renal replacement therapy for duration of liver transplant surgery.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age 18 or older and able to sign consent (or surrogate)
* Receiving liver or combined liver-kidney transplant
* eGFR \< or equal to 40 ml/min immediately prior to transplant or currently on any form of renal replacement therapy for acute kidney injury or end-stage renal disease
* Pre-operative potassium of \< or equal to 5.5 mEq/L