Living Donor Liver Transplantation to Patients With Portal Vein Thrombosis
NCT ID: NCT05132192
Last Updated: 2021-11-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
335 participants
OBSERVATIONAL
2013-01-01
2020-10-30
Brief Summary
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Detailed Description
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Data relating to this study including patient history, preoperative laboratory and imaging test results, reports of surgical procedures or interventions, intraoperative anesthesia records, post-operative laboratory trends, and postoperative complications were extracted from the computer-based data management system and prospectively maintained in transplant databases in both centers. Recipients of LDLT were divided in two groups according to the presence or absence of PVT.
Portal flow measurements were recorded with VeriQ (Medistim ASA, Oslo, Norway) Doppler flowmeter device in one of the centers later in the study period.
The follow-up and recordings of the patients were maintained in the outpatient clinics of the two centers.
The most serious complication experienced by each patient was recorded according to the Clavien-Dindo classification Primary outcome of the current study was the survival rates of patients with and without PVT Secondary outcomes of the study included morbidity in patients with and without PVT after LDLT, risk factors of mortality after LDLT to patients with PVT and comparison of intraoperative portal flow measurements between patients with and without PVT
Conditions
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Keywords
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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PVT
Patients with pretransplant portal vein thrombosis
living donor liver transplantation
Living donor liver transplantation
Thrombectomy or interposition graft
Portal flow restoration due to PVT in any manner
non-PVT
Patients without pretransplant portal vein thrombosis
living donor liver transplantation
Living donor liver transplantation
Interventions
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living donor liver transplantation
Living donor liver transplantation
Thrombectomy or interposition graft
Portal flow restoration due to PVT in any manner
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Deceased donor liver transplants
18 Years
ALL
No
Sponsors
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Ankara University
OTHER
Ankara Guven Hospital
UNKNOWN
Elvan Onur Kirimker
OTHER
Responsible Party
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Elvan Onur Kirimker
Attending surgeon at Dept of Surgery
Principal Investigators
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Elvan O Kirimker, MD
Role: PRINCIPAL_INVESTIGATOR
Ankara University
References
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Conzen KD, Pomfret EA. Liver transplant in patients with portal vein thrombosis: Medical and surgical requirements. Liver Transpl. 2017 Oct;23(S1):S59-S63. doi: 10.1002/lt.24856. No abstract available.
Yerdel MA, Gunson B, Mirza D, Karayalcin K, Olliff S, Buckels J, Mayer D, McMaster P, Pirenne J. Portal vein thrombosis in adults undergoing liver transplantation: risk factors, screening, management, and outcome. Transplantation. 2000 May 15;69(9):1873-81. doi: 10.1097/00007890-200005150-00023.
Ravaioli M, Zanello M, Grazi GL, Ercolani G, Cescon M, Del Gaudio M, Cucchetti A, Pinna AD. Portal vein thrombosis and liver transplantation: evolution during 10 years of experience at the University of Bologna. Ann Surg. 2011 Feb;253(2):378-84. doi: 10.1097/SLA.0b013e318206818b.
Zanetto A, Rodriguez-Kastro KI, Germani G, Ferrarese A, Cillo U, Burra P, Senzolo M. Mortality in liver transplant recipients with portal vein thrombosis - an updated meta-analysis. Transpl Int. 2018 Dec;31(12):1318-1329. doi: 10.1111/tri.13353. Epub 2018 Oct 23.
Qi X, Dai J, Jia J, Ren W, Yang M, Li H, Fan D, Guo X. Association between portal vein thrombosis and survival of liver transplant recipients: a systematic review and meta-analysis of observational studies. J Gastrointestin Liver Dis. 2015 Mar;24(1):51-9, 4 p following 59. doi: 10.15403/jgld.2014.1121.qix.
Hibi T, Nishida S, Levi DM, Selvaggi G, Tekin A, Fan J, Ruiz P, Tzakis AG. When and why portal vein thrombosis matters in liver transplantation: a critical audit of 174 cases. Ann Surg. 2014 Apr;259(4):760-6. doi: 10.1097/SLA.0000000000000252.
Other Identifiers
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PVT-LDLT-ANK
Identifier Type: -
Identifier Source: org_study_id