A Study of the Correlation Between Portal Vein Thrombosis and Prognosis of Liver Transplantation

NCT ID: NCT06513780

Last Updated: 2025-09-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

700 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2025-12-31

Brief Summary

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The goal of this observational study is to investigate the correlation between portal vein thrombosis (PVT) and the prognosis of liver transplantation. The main questions it aims to address are:

What is the prevalence of PVT? What are the risk factors associated with PVT? What is the prognostic impact of preoperative PVT on liver transplantation?

Participants are divided into two groups: the PVT group and the non-PVT group. The investigators will comparatively analyze the data of both groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, and clarify the prognostic effects of PVT.

Detailed Description

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The investigators aim to investigate the prevalence and risk factors of PVT, to develop a novel grading or rating system for PVT, and to explore the prognostic impact of preoperative PVT in liver transplantation.

The investigators will:

Recruit patients according to the inclusion/exclusion criteria and obtain signed informed consents. They will collect demographic and laboratory characteristics and classify patients into the PVT group and the non-PVT group based on preoperative ultrasound and/or computed tomography.

Collect patients' perioperative medical imaging, surgical procedures, pathology reports, postoperative treatments, follow-up data, and clinical endpoints.

Comparatively analyze the data of the PVT and non-PVT groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, clarify the prognostic effects of PVT, and propose a grading/rating system for PVT.

Conditions

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Portal Vein Thrombosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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PVT

Participants who meet the inclusion criteria for portal vein thrombosis prior to liver transplantation

Observation

Intervention Type OTHER

No intervention were made.

non-PVT

Participants who meet the inclusion criteria for the absence of portal vein thrombosis prior to liver transplantation.

Observation

Intervention Type OTHER

No intervention were made.

Interventions

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Observation

No intervention were made.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Liver transplantation recipients
2. Aged 18 years or older.

Exclusion Criteria

1. Retransplantation
2. Multi-organ transplantation
3. Portal vein tumor thrombus
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ru-zhou Cai

OTHER

Sponsor Role lead

Responsible Party

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Ru-zhou Cai

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Beijing Friendship Hospital, Capital Medical University

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Ru-zhou Cai, M.D.

Role: CONTACT

18722563616

Facility Contacts

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Ruzhou Cai

Role: primary

18722563616

Other Identifiers

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2024-P2-187-01

Identifier Type: -

Identifier Source: org_study_id

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