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The Association of Endothelial Dysfunction and Cardiac Allograft Vasculopathy

NCT ID: NCT00173914

Last Updated: 2005-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-03-31

Brief Summary

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Progressive cardiac allograft vasculopathy (CAV) is a serious complication in long-term survivors after heart transplantation. Therefore, we hypothesize that CAV is a diffuse and progressive process, and endothelial function may play an important role in predicting clinical outcome after heart transplantation. Therefore, this single-blinded study is designed to evaluate endothelial function, microvascular flow response and morphology of coronary artery in cardiac allografts,

1. The simultaneous use of IVUS and Doppler wire instrumentation in different pharmacological stress;
2. Tl-201 SPECT (dipyridamole stress/rest); to evaluate the correlation of endothelial function, coronary morphology change and Tl-201 dipyridamole stress myocardial perfusion image.

Detailed Description

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Conditions

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Heart Transplantation

Keywords

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1. Transplant vasculopathy 2. Endothelial dysfunction 3. Myocardial perfusion imaging 4. Intravascular vascular ultrasound

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

1\. Heart transplant receipients who undergoing the coronary angiographic follow-up as standard protocols.

Exclusion Criteria

1. Acute illness conditions including infection, congestive heart failure (NYHA Fc III, IV), etc.
2. Coronary angiographic finding: coronary stenosis\>30% (as grade III, IV by Klauss V et al, Am J Cardiol 1995; 76:463-6).
3. Creatinine \>3.0 mg/dl
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Chii-Ming Lee, MD, phD

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Chii-Ming Lee, MD, phD

Role: CONTACT

Phone: 886-2-23123456

Email: [email protected]

Facility Contacts

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Chii-Ming Lee, MD, phD

Role: primary

Other Identifiers

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NTUH 92M011

Identifier Type: -

Identifier Source: secondary_id

9200000478

Identifier Type: -

Identifier Source: org_study_id