The Anabolic and Catabolic Effect of Loaded and Unloaded Exercise on Articular Cartilage Health

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-27

Study Completion Date

2020-03-01

Brief Summary

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The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Control

The control condition did 30 minutes of walking exercise with their own body mass.

Group Type EXPERIMENTAL

Control Condition

Intervention Type OTHER

Control (no alteration to body mass).

+12% Body Mass

The +12% body mass condition did 30 minutes of walking exercise wearing a weighted vest with +12% of their body mass applied.

Group Type EXPERIMENTAL

+12% Body Mass

Intervention Type OTHER

Loaded walking exercise (12% increase in body mass using a weighted vest).

-12% Body Mass

The -12% body mass condition did 30 minutes of walking exercise using a lower body positive pressure treadmill with -12% of their body mass applied.

Group Type EXPERIMENTAL

-12% Body Mass

Intervention Type OTHER

Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).

Interventions

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Control Condition

Control (no alteration to body mass).

Intervention Type OTHER

+12% Body Mass

Loaded walking exercise (12% increase in body mass using a weighted vest).

Intervention Type OTHER

-12% Body Mass

Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy
* 18-30 years old

Exclusion Criteria

* Traumatic injury to the lower extremity in the past year
* Hip, knee, or ankle surgery
* Radiographic evidence of joint degeneration
* Cardiovascular disease
* Ankylosing spondylitis
* Psoriatic arthritis
* Chronic reactive arthritis
* Renal problems requiring peritoneal dialysis or hemodialysis
* Not currently using any prescription or non-prescription medications and/or nutritional supplements

Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes