Screening for Risk Factors of Prediabetes Among Adult Patients at Sohag University Hospital
NCT ID: NCT05864183
Last Updated: 2023-05-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2023-04-15
2023-12-31
Brief Summary
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* during the average 3 years of follow-up Prediabetes is diagnosed based on laboratory tests: fasting plasma glucose level (100-125 mg/dl) ;HbA1c, (5.7-6.4%) or plasma glucose level after an oral glucose tolerance test ( 140-199 mg/dl).
* Reports estimate that more than 470 million people will have prediabetes by 2030.
* According to an expert panel of the American Diabetes Association, up to 70% of individuals with prediabetes will eventually develop diabetes.
* Observational evidence suggests as association between prediabetes and complications of diabetes such early nephropathy(10%) , small fiber neuropathy(18-25 %), early retinopathy (8-12%) and risk of macrovascular disease (52%) .
* Screening for prediabetes is designed to save lives or enhance an individual's quality of life by early detection so that screening will minimize the risk of developing diabetes or its complications .
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Detailed Description
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* Prediabetes screening is also required to minimize medical costs such as hospitalization, outpatient care, surgery, medications, and laboratory test costs .
* Several studies had shown efficacy of lifestyle interventions in diabetes prevention by targeting obesity with increase in physical activity and dietary changes with a relative risk reduction of 40%-70% in adults with prediabetes ,also there is increasing evidence to prove the efficacy of pharmacotherapy in prevention of diabetes in adults with prediabetes
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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case group
prediabetic
HbA1c
HbA1c will be measured for all patients to minimize the risk of developing diabetes or its complications .
lipid profile
lipid profile will be measured for all patients to minimize the risk of developing diabetes or its complications .
CBC
CBC will be measured for all patients to minimize the risk of developing diabetes or its complications
Alb/cr ratio
Alb/cr will be measured for all patients to minimize the risk of developing diabetes or its complications
serum creatinine .
serum creatinine will be measured for all patients to minimize the risk of developing diabetes or its complications
CRP
CRP will be measured for all patients to minimize the risk of developing diabetes or its complications
urine analysis
urine analysis will be measured for all patients to minimize the risk of developing diabetes or its complications
ECG
ECG will be done for all patients to minimize the risk of developing diabetes or its complications
fundus examination
fundus examination will be done for all patients to minimize the risk of developing diabetes or its complications
control group
non prediabetic
HbA1c
HbA1c will be measured for all patients to minimize the risk of developing diabetes or its complications .
lipid profile
lipid profile will be measured for all patients to minimize the risk of developing diabetes or its complications .
CBC
CBC will be measured for all patients to minimize the risk of developing diabetes or its complications
Alb/cr ratio
Alb/cr will be measured for all patients to minimize the risk of developing diabetes or its complications
serum creatinine .
serum creatinine will be measured for all patients to minimize the risk of developing diabetes or its complications
CRP
CRP will be measured for all patients to minimize the risk of developing diabetes or its complications
urine analysis
urine analysis will be measured for all patients to minimize the risk of developing diabetes or its complications
ECG
ECG will be done for all patients to minimize the risk of developing diabetes or its complications
fundus examination
fundus examination will be done for all patients to minimize the risk of developing diabetes or its complications
Interventions
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HbA1c
HbA1c will be measured for all patients to minimize the risk of developing diabetes or its complications .
lipid profile
lipid profile will be measured for all patients to minimize the risk of developing diabetes or its complications .
CBC
CBC will be measured for all patients to minimize the risk of developing diabetes or its complications
Alb/cr ratio
Alb/cr will be measured for all patients to minimize the risk of developing diabetes or its complications
serum creatinine .
serum creatinine will be measured for all patients to minimize the risk of developing diabetes or its complications
CRP
CRP will be measured for all patients to minimize the risk of developing diabetes or its complications
urine analysis
urine analysis will be measured for all patients to minimize the risk of developing diabetes or its complications
ECG
ECG will be done for all patients to minimize the risk of developing diabetes or its complications
fundus examination
fundus examination will be done for all patients to minimize the risk of developing diabetes or its complications
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* pregnancy .
* chronic depleting diseases,
* Those who were taking drugs known to influence blood glucose levels e.g. metformin, thiazolidinedione and steroids.
18 Years
ALL
Yes
Sponsors
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Sohag University
OTHER
Responsible Party
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Nermin Fathy Ezzat
internal medicine resident at faculty of medicine Sohag university
Locations
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Sohag university hospital
Sohag, , Egypt
Countries
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Central Contacts
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Adel A El sayed, professor
Role: CONTACT
Facility Contacts
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Magdy M Amin, professor
Role: primary
References
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Tabak AG, Herder C, Rathmann W, Brunner EJ, Kivimaki M. Prediabetes: a high-risk state for diabetes development. Lancet. 2012 Jun 16;379(9833):2279-90. doi: 10.1016/S0140-6736(12)60283-9. Epub 2012 Jun 9.
Beulens J, Rutters F, Ryden L, Schnell O, Mellbin L, Hart HE, Vos RC. Risk and management of pre-diabetes. Eur J Prev Cardiol. 2019 Dec;26(2_suppl):47-54. doi: 10.1177/2047487319880041.
Vas PRJ, Alberti KG, Edmonds ME. Prediabetes: moving away from a glucocentric definition. Lancet Diabetes Endocrinol. 2017 Nov;5(11):848-849. doi: 10.1016/S2213-8587(17)30234-6. Epub 2017 Aug 3. No abstract available.
Other Identifiers
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Soh-Med-23-04-20MS
Identifier Type: -
Identifier Source: org_study_id
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