Serum Magnesium Level in Type 2 Diabetes Mellitus

NCT ID: NCT06059833

Last Updated: 2023-09-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-30

Study Completion Date

2024-09-30

Brief Summary

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Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. It may be due to impaired insulin secretion, resistance to peripheral actions of insulin, or both . Chronic hyperglycemia in synergy with the other metabolic aberrations in patients with diabetes mellitus can cause damage to various organ systems, leading to the development of disabling and life-threatening health complications, most prominent of which are microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular complications leading to a 2-fold to 4-fold increased risk of cardiovascular diseases Mg2+ deficiency is usually identified by the measurement of serum Mg2+ concentration. Hypomagnesemia is defined by a serum Mg2+ concentration \< 0.75 mmol/L, but a deficiency due to low dietary intake in otherwise healthy people is uncommon. Although overt signs of clinical Mg2+ deficiency are not routinely recognized in the healthy population, relatively low Mg2+ intake and/or Mg2+ status have been shown to be associated with chronic diseases, including cardiovascular disease, T2DM, osteoporosis, pulmonary disease, depression, migraine headaches, inflammation, and cancer

Detailed Description

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Conditions

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Diabetes Mellitus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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cases group

Magnesium

Intervention Type DIAGNOSTIC_TEST

The aim of the study is to evaluate serum Mg level in type 2 DM patients.

control group

Magnesium

Intervention Type DIAGNOSTIC_TEST

The aim of the study is to evaluate serum Mg level in type 2 DM patients.

Interventions

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Magnesium

The aim of the study is to evaluate serum Mg level in type 2 DM patients.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* • Type 2 Diabetes Mellitus according to WHO criteria.

Exclusion Criteria

* • Renal failure patients.

* Type I DM patients.
* Acute pancreatitis.
* Hyperthyroidism.
* Hyperparathyroidism.
* Malignancies.
* Patients on loop/thiazide diuretics.
* Patients on Mg supplement.
* Patients on Mg containing antacids.
* Any other conditions causing low Mg levels were excluded from the study.
Minimum Eligible Age

30 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Hasnaa Mohamed Kamel

Resident-clinical pathology department-sohag hospital university

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sohag university Hospital

Sohag, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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hassnaa M kamel, resident

Role: CONTACT

01009700227

Elham o Hamd, professor

Role: CONTACT

01063090309

Facility Contacts

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Magdy M Amin, professor

Role: primary

References

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Zheng L, Zhu X, Yang K, Zhu M, Farooqi AA, Kang D, Sun M, Xu Y, Lin X, Feng Y, Liang F, Zhang F, Linhardt RJ. Correction: Zheng, L., et al. PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus, Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways. Polymers 2018, 10, 1043. Polymers (Basel). 2021 Jan 5;13(1):166. doi: 10.3390/polym13010166.

Reference Type BACKGROUND
PMID: 33466568 (View on PubMed)

Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Martin C. Pathophysiology of Type 2 Diabetes Mellitus. Int J Mol Sci. 2020 Aug 30;21(17):6275. doi: 10.3390/ijms21176275.

Reference Type BACKGROUND
PMID: 32872570 (View on PubMed)

Piuri G, Zocchi M, Della Porta M, Ficara V, Manoni M, Zuccotti GV, Pinotti L, Maier JA, Cazzola R. Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Nutrients. 2021 Jan 22;13(2):320. doi: 10.3390/nu13020320.

Reference Type BACKGROUND
PMID: 33499378 (View on PubMed)

Feng J, Wang H, Jing Z, Wang Y, Cheng Y, Wang W, Sun W. Role of Magnesium in Type 2 Diabetes Mellitus. Biol Trace Elem Res. 2020 Jul;196(1):74-85. doi: 10.1007/s12011-019-01922-0. Epub 2019 Nov 11.

Reference Type BACKGROUND
PMID: 31713111 (View on PubMed)

Other Identifiers

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Soh-Med-23-07-14MS

Identifier Type: -

Identifier Source: org_study_id

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