Thyroid Dysfunction in Patients With Type 2 Diabetes With Early Diabetic Nephropathy.

NCT ID: NCT03154398

Last Updated: 2021-02-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-01
• Study Completion Date: 2019-12-01

Brief Summary

Diabetes Mellitus is the most common disorder seen. The impact of this disease on the quality of life, and on morbidity and mortality through the complications that affect the small and large vessels resulting in retinopathy, nephropathy, neuropathy, and ischemic heart disease has been emphasized by the findings of the national commission (USA) on diabetes .

So, there was curiosity to understand and learn the association of this disorder with another common endocrine gland function that is thyroid gland . The association between these two disorders has long been recognized although the prevalence of thyroid dysfunction in diabetic population varies widely between studies. With insulin and thyroid hormone being intimately involved in cellular metabolism and thus excess or deficit of these hormones result in functional derangement of the other .

Diabetic patients have higher prevalence of thyroid disorder when compared with the normal population. Diabetic women are more frequently affected than men and hypothyroidism is more common than thyrotoxicosis.

As Hyperthyroidism impairs glycemic control in diabetic subjects, while hypothyroidism may increase susceptibility to hypoglycemia thus complicating diabetes management so Severe diabetic complications where noted in patients with sub- clinical hypothyroidism . Sub-clinical hypothyroidism is an independent risk factor for development of diabetic nephropathy.

Detailed Description

Recognition and treatment of thyroid dysfunction in diabetic patients will benefit glycemic control and improve general well-being Diabetic nephropathy, a major microvascular complication of type 2 diabetes mellitus, is an important cause of chronic kidney disease. It results from interactions between hemodynamic and metabolic factors.

Conditions

Evaluation Thyroid Functions in Diabetic Patient

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

1

case control

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Type 2 diabetes mellitus and with diabetic nephropathy.

Exclusion Criteria

• 1) Insulin dependent diabetes 2) Patients with:

• Gestational diabetes mellitus.
• Steroid induced Diabetes.

3) Thyroid disease

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

maria hamdy

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

maria hamdy

Role: STUDY_DIRECTOR

Assiut University

Locations

Assuit University

Asyut, , Egypt

Countries

Egypt

Other Identifiers

Assiut1991

Identifier Type: -

Identifier Source: org_study_id