Comparison of Th1 Cytokine Levels Between Type 1 and Type 2 Diabetes

NCT ID: NCT02860611

Last Updated: 2016-08-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-02-28

Study Completion Date

2016-06-30

Brief Summary

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Recent reports show increased prevalence of obesity in patients with type 1 diabetes (T1DP)s while some studies stated that patients with type 2 diabetes (T2DPs) have islet cell auto-antibodies. These results raise the question of a common pathway in T1DM and T2DM via an association with T helper cells. In this study investigators aimed to investigate the difference between T helper 1 (Th1) cytokines levels in T1DPs, T2DPs and healthy subjects.

The study included 114 T1DPs on insulin treatment, 35 newly diagnosed T2DPs who had not used oral antidiabetics but insulin before and 31 healthy subjects (CG).

Serum interferon gamma (IFN-γ), interleukin-2 (IL-2) and tumor necrosis factor alpha (TNF-α) levels were measured using ELISA method. Serum levels of those cytokines in T1DPs were compared with those in T2DPs and controls.

Detailed Description

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Conditions

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Type 1 Diabetes Type 2 Diabetes

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Type 1 Diabetes

Patients with type 1 diabetes

No interventions assigned to this group

Type 2 Diabetes

Patients with type 2 diabetes

No interventions assigned to this group

Control

Healthy volunteers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Being \>18 years old
* Giving consent to participate

Exclusion Criteria

* Acute and chronic inflammatory diseases
* significant concomitant disease likely to interfere with glucose metabolism,
* malignancies,
* hemoglobinopathies,
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Istanbul Medeniyet University

OTHER

Sponsor Role lead

Responsible Party

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Gonca Incemehmet Tamer

Assoc. Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gonca Tamer

Role: PRINCIPAL_INVESTIGATOR

Istanbul Medeniyet University

Locations

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Medeniyet University Goztepe Training and Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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IstanbulMU

Identifier Type: -

Identifier Source: org_study_id

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