Study on the Relationship Between Iodine Nutrition and Thyroid Diseases in the Elderly
NCT ID: NCT05716191
Last Updated: 2023-08-16
Study Results
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Basic Information
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RECRUITING
1000 participants
OBSERVATIONAL
2023-02-17
2025-12-30
Brief Summary
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1. to clarify the differences in the prevalence of thyroid diseases in the elderly with different iodine nutrition backgrounds.
2. to analyze the effects of mild iodine deficiency and iodine excess on the thyroid health of the elderly.
3. to explore the hazard threshold of iodine intake for old people.
4. to compare the differences in thyroid disease and iodine nutritional status between young and middle-aged people and old people.
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Detailed Description
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Investigators will separately include adults ( middle-aged people and old people) in iodine-deficient, iodine-appropriate, and iodine-excessive areas. Venous blood will be collected to measure thyroid function and serum iodine. Thyroid volume and nodular disease were determined by B-ultrasonography. Drinking water, saliva and 24-h and spot urinary samples will be collected to precisely evaluate the daily iodine intake. Multiple indicators were used to accurately evaluate the iodine intake level of the subjects, and understand the differences in the prevalence of thyroid diseases in the elderly under different iodine nutrition backgrounds. Besides, the differences in thyroid disease and iodine nutritional status between young and middle-aged people and old people will be compared.
Part 2：A survey on the iodine nutrition status in the elderly with/without thyroid disease in iodine-appropriate areas.
Investigators will collect basic information (height, weight, age, other medical histories, etc.) and thyroid disease history information. Thyroid B-ultrasound and thyroid function tests were used to understand the current thyroid status of the elderly. The iodine dietary frequency questionnaire was used to assess the long-term iodine intake level of the survey subjects, and spot urinary iodine, 24-h urinary iodine and salivary iodine were used to assess the short-term iodine intake level of the survey subjects.
Conditions
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Study Design
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ECOLOGIC_OR_COMMUNITY
CROSS_SECTIONAL
Interventions
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Naturally different iodine levels exposure
A cross-sectional survey of thyroid disease in elderly people in areas with different iodine nutrition backgrounds
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. adults with special dietary habits
3. adults taking iodine-containing drugs or supplements
4. adults with protein or nutritional deficiencies
18 Years
ALL
Yes
Sponsors
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Tianjin Medical University General Hospital
OTHER
Shandong Provincial Institute for Endemic Disease Control
UNKNOWN
Tianjin Medical University
OTHER
Responsible Party
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Wenxing Guo
Lecturer
Principal Investigators
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Wenxing Guo, Doctor
Role: STUDY_CHAIR
Public Health School, Tianjin Medical University
Locations
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Gansu provincial center for disease control and prevention
Lanzhou, Gansu, China
Shandong provincial institute for endemic disease control
Jinan, Shandong, China
Tianjin Medical University
Tianjin, Tianjin Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Yanling Wang
Role: primary
Xiaoming Wang
Role: primary
References
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Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015 Apr;3(4):286-95. doi: 10.1016/S2213-8587(14)70225-6. Epub 2015 Jan 13.
Leung AM, Braverman LE. Consequences of excess iodine. Nat Rev Endocrinol. 2014 Mar;10(3):136-42. doi: 10.1038/nrendo.2013.251. Epub 2013 Dec 17.
Li Y, Teng D, Ba J, Chen B, Du J, He L, Lai X, Teng X, Shi X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Ning G, Mu Y, Zhao J, Shan Z, Teng W. Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence from 31 Provinces of Mainland China. Thyroid. 2020 Apr;30(4):568-579. doi: 10.1089/thy.2019.0067. Epub 2020 Mar 24.
Miller JC, MacDonell SO, Gray AR, Reid MR, Barr DJ, Thomson CD, Houghton LA. Iodine Status of New Zealand Elderly Residents in Long-Term Residential Care. Nutrients. 2016 Jul 23;8(8):445. doi: 10.3390/nu8080445.
Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S, Pedersen IB, Carle A. Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):13-27. doi: 10.1016/j.beem.2009.08.013.
Limanova Z. [Thyroid disease in the elderly]. Vnitr Lek. 2018 Winter;64(11):993-1002. Czech.
Zhai X, Zhang L, Chen L, Lian X, Liu C, Shi B, Shi L, Tong N, Wang S, Weng J, Zhao J, Teng X, Yu X, Lai Y, Wang W, Li C, Mao J, Li Y, Fan C, Li L, Shan Z, Teng W. An Age-Specific Serum Thyrotropin Reference Range for the Diagnosis of Thyroid Diseases in Older Adults: A Cross-Sectional Survey in China. Thyroid. 2018 Dec;28(12):1571-1579. doi: 10.1089/thy.2017.0715. Epub 2018 Nov 27.
Barbesino G. Thyroid Function Changes in the Elderly and Their Relationship to Cardiovascular Health: A Mini-Review. Gerontology. 2019;65(1):1-8. doi: 10.1159/000490911. Epub 2018 Jul 20.
Iacone R, Iaccarino Idelson P, Russo O, Donfrancesco C, Krogh V, Sieri S, Macchia PE, Formisano P, Lo Noce C, Palmieri L, Galeone D, Rendina D, Galletti F, Di Lenarda A, Giampaoli S, Strazzullo P, On Behalf Of The Minisal-Gircsi Study Group. Iodine Intake from Food and Iodized Salt as Related to Dietary Salt Consumption in the Italian Adult General Population. Nutrients. 2021 Sep 30;13(10):3486. doi: 10.3390/nu13103486.
Jin Q, Wang Z, Li J, Zhang H, Liu M, Wang C, Guo W, Zhang W. Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly. Biol Trace Elem Res. 2025 Jul;203(7):3470-3478. doi: 10.1007/s12011-024-04420-0. Epub 2024 Oct 23.
Other Identifiers
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NSFC-82204041
Identifier Type: -
Identifier Source: org_study_id
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