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Thyroid Disorders in Malaysia...

Thyroid Disorders in Malaysia: A Nationwide Multicentre Study

NCT ID: NCT02190214

Last Updated: 2016-10-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2498 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-08-31

Study Completion Date

2016-09-30

Brief Summary

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This will be a population based study looking at the prevalence of thyroid disorders in Malaysia (including hypo- and hyperthyroidism, subclinical hypo- or hyperthyroidism) and its association with different ethnicity and iodine status. The study will also look at genetic susceptibility for autoimmune thyroid disorders in the Malaysian population

General hypotheses:

The prevalence of thyroid disorders in Malaysia is 10% for hypothyroidism and 2% for hyperthyroidism Hypo- and hyperthyroidism is associated with iodine status in our population There are different susceptibility gene for autoimmune thyroid disorder in different ethnicity in our population

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Detailed Description

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This will be a cross-sectional population based study involving Malaysian adults (aged 18 year old and above). Cluster sampling will be used to select respondents that will be representative of the Malaysian population. Selected respondent will be interviewed, anthropometric measurement taken, blood and urine sample taken.

Blood will be analyzed for thyroid function (thyroxine, triiodothyronine and thyroid stimulating hormone), autoantibodies (anti-thyroperoxidase and anti-thyroglobulin). Urine will be analyzed for urinary iodine.

Those diagnosed with autoimmune thyroid disorders with strong family history of thyroid disorders (multiplex multi-generation family involvement) will have their blood sent for whole exome sequencing and linkage analysis done to identify possible susceptible gene for autoimmune thyroid disorders

Respondents detected to have hypo- or hyper- and subclinical hypo- or hyperthyroidism will be referred to their nearest health centre for further evaluation and treatment appropriate for their condition.

Conditions

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Hypothyroidism Subclinical Hypothyroidism Hyperthyroidism Subclinical Hyperthyroidism Graves Disease Hashimoto's Thyroiditis Iodine Deficiency Genetic Susceptibility

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Aged equal or more than 18 years old at the time of sampling
* Malaysian citizen

Exclusion Criteria

* Respondents who did not give consent

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Dr Mohamnmad Arif Shahar

Assist Prof

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nor Azmi Kamaruddin, MBBS, MMed

Role: PRINCIPAL_INVESTIGATOR

National University of Malaysia

Norlela Sukor, MMed, Phd

Role: PRINCIPAL_INVESTIGATOR

National University of Malaysia

Norhanita Othman

Role: PRINCIPAL_INVESTIGATOR

National University of Malaysia

Johari Ali

Role: PRINCIPAL_INVESTIGATOR

University of Malaya

Shirenee Vethakkan

Role: PRINCIPAL_INVESTIGATOR

University of Malaya

Siew Kim Kwa

Role: PRINCIPAL_INVESTIGATOR

IMU University, Malaysia