Thyroid Profiles in Patients With Acute Illness

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-15

Study Completion Date

2025-01-30

Brief Summary

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Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.

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Detailed Description

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Recently, there has been a growing body of evidence that subclinical thyroid dysfunction as a contributor to the increase of cardiovascular events. Elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine (FT4) and free triiodothyronine (FT3) levels have been associated with worse heart failure and dyslipidemia. Furthermore, higher risk of atrial fibrillation has been linked tp thyroid abnormalities in these patients.

Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients. This study aimed at evaluating the prevalence of thyroid function abnormalities in patients admitted to hospital with acute illness and their temporal changes and impact on mortality during hospitalization and at 1 year. Serum level of thyroid stimulating hormone and free T4 and T3 measured on admission. Clinical and laboratory profiles of patients with abnormal thyroid function (ATF group) will be compared to those with normal thyroid function (NTF group). Short and long term survival of both groups were compares as well.

Conditions

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Thyroid Dysfunction Acute Illness

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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GROUP 1: Acute illness and abnormal thyroid function

Patients admitted to the hospital with acute illness and found to have thyroid function abnormalities.

Performing blood thyroid test (TSH, FT4, FT3)

Intervention Type OTHER

Blood test as above

GROUP 2: Acute illness and normal thyroid function

Patients admitted to the hospital with acute illness and found to have normal thyroid function.

Performing blood thyroid test (TSH, FT4, FT3)

Intervention Type OTHER

Blood test as above

Interventions

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Performing blood thyroid test (TSH, FT4, FT3)

Blood test as above

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Hospital admission
* Adults aged 18 years and above
* Willing to sign an informed consent
* Diagnosis on admission is acute illness that includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure.