Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

NCT ID: NCT00770016

Last Updated: 2010-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2011-01-31

Brief Summary

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The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Detailed Description

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Conditions

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Hypothyroidism

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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1

the aim of the present study is to characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic - intramyocellular lipids in 12 adult patients, recently diagnosed with hypothyroidism

Group Type EXPERIMENTAL

Levothyroxin

Intervention Type DRUG

Dosage regulation will follow the local recommendations of treatment

Interventions

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Levothyroxin

Dosage regulation will follow the local recommendations of treatment

Intervention Type DRUG

Other Intervention Names

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Eltroxin (Levothyroxin, GlaxoSmithKline Pharma)

Eligibility Criteria

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Inclusion Criteria

* written informed consent
* must be of legal age and competent
* Age \> 18 years
* presently diagnosed with hypothyroidism

Exclusion Criteria

* alcohol consumption \>21 units per week
* Malignant disease
* pregnancy
* magnetic implants or material in the body
* BMI \> 30
* Heart disease (NYHA \>2)
* Uncontrolled hypertension
* Manifest diabetes mellitus
* Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MR Research Center, Skejby Sygehus, Brendstrupgaardsvej 100, 8200 Aarhus N

UNKNOWN

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Norrebrogade 44, 8000 Aarhus C

Locations

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Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus,

Aarhus, , Denmark

Site Status

Countries

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Denmark

Related Links

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Other Identifiers

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LM_HYPO_2008

Identifier Type: -

Identifier Source: org_study_id