Metabolomics of Thyroid Hormones

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

332 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-12

Study Completion Date

2021-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to develop a metabolome signature of thyroid hormone status. The metabolome signature could be useful in diagnosis and treatment of thyroid dysfunction diseases, especially in cases where TSH cannot be reliably used.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Natural History of Thyroid Function Disorders

NCT00001159

Hyperthyroidism Hypothyroidism Grave's Disease

RECRUITING

Central Hypothyroidism, a Novel Laboratory Measurement

NCT01280292

Central Hypothyroidism

UNKNOWN NA

Thyroid Profiles in Patients With Acute Illness

NCT05980923

Thyroid Dysfunction Acute Illness

WITHDRAWN

Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation

NCT00360074

Secondary Hypothyroidism Hypopituitarism Hyperlipidemias

COMPLETED PHASE4

Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3

NCT00812149

Thyroid Disease Healthy

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Primary Hypothyroidism is a frequent endocrine disorder, where the thyroid gland does not produce sufficient amounts of thyroid hormones. The substitution therapy is guided by measurement of the pituitary gland hormone thyrotropin (TSH). Patients with central hypothyroidism in whom pituitary insufficiency leads to hypothyroidism, TSH cannot be used to guide therapy. So far there are no reliable methods for therapy control in patients with central hypothyroidism.

The measurement of small endogenous metabolites might give investigators a metabolomics profile. This could help to discriminate between euthyroid, hypothyroid and hyperthyroid state and therefore could be used for diagnosis and therapy control of thyroid dysfunction diseases.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Central Hypothyroidism Hypothyroidism Hyperthyroidism

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy volunteers

* Blood sampling (fT3, fT4, TSH, Lipids, Glucose, HbA1c)
* Indirect calorimetry
* Dual energy X-ray Absorptiometry (DXA)