The Influence of Different Thyroid Autoantibodies on Thyroid Function and Pregnancy Outcome After Assisted Reproductive Technology
NCT ID: NCT04019509
Last Updated: 2019-07-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
900 participants
INTERVENTIONAL
2019-01-01
2022-09-01
Brief Summary
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The objectives of the present study are:
1. To monitor the course of thyroid function during pregnancy and to compare between women with and without thyroid autoantibodies.
2. Compare pregnancy outcome between women with and without thyroid antibodies
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Detailed Description
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A possible explanation for this is, an influence of thyroid autoantibodies on the functioning of the thyroid gland. It is therefore recommended to check thyroid gland function and for the presence of autoantibodies before pregnancy. In general, 2 types of thyroid autoantibodies are known: anti-thyreoperoxidase autoantibodies and anti-thyroglobulin autoantibodies.
In case of abnormal thyroid function, treatment is sometimes necessary in regards to fertility. The risk of abnormal thyroid function is increased in women with thyroid autoantibodies during pregnancy. Therefore, thyroid function is regularly monitored during pregnancy in women with thyroid antibodies. The influence of thyroid autoantibodies on thyroid function in pregnancy after fertility treatment is not well known.
The objectives of the present study are:
1. To monitor the course of thyroid function during pregnancy and to compare between women with and without thyroid autoantibodies.
2. Compare pregnancy outcome between women with and without thyroid antibodies
Conditions
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Study Design
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NON_RANDOMIZED
FACTORIAL
DIAGNOSTIC
NONE
Study Groups
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Tg AB positive, TPO AB negative
Includes patients with only anti-thyroglobuline autoantibodies present and no anti-thyreoperoxydase antibodies at start of fertility treatment.
blood test
blood test for thyroid antibodies and thyroid function (TSH, FT4)
follow up treatment outcome
questionnaire for treatment outcome: pregnancy, no pregnancy, miscarriage, delivery
Tg AB negative, TPO AB negative
Includes patients without thyroid autoantibodies at start of fertility treatment
blood test
blood test for thyroid antibodies and thyroid function (TSH, FT4)
follow up treatment outcome
questionnaire for treatment outcome: pregnancy, no pregnancy, miscarriage, delivery
Tg AB positive, TPO AB positive
Includes patients with anti-thyroglobuline autoantibodies and anti-thyreoperoxydase antibodies at start of fertility treatment.
blood test
blood test for thyroid antibodies and thyroid function (TSH, FT4)
follow up treatment outcome
questionnaire for treatment outcome: pregnancy, no pregnancy, miscarriage, delivery
Interventions
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blood test
blood test for thyroid antibodies and thyroid function (TSH, FT4)
follow up treatment outcome
questionnaire for treatment outcome: pregnancy, no pregnancy, miscarriage, delivery
Eligibility Criteria
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Inclusion Criteria
* age \>= 18 and \<= 36 years
* body mass index between 18 and 35
Exclusion Criteria
* Patients being treated with levothyroxine or antithyroid drugs
* Patients being treated with glucocorticosteroids
* Patients undergoing in vitro maturation or preimplantation genetic testing.
* Poor responders during IVF/ICSI stimulation, using the Bologna criteria
18 Years
36 Years
FEMALE
Yes
Sponsors
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Universitair Ziekenhuis Brussel
OTHER
Responsible Party
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Valerie Uvin
MD
Principal Investigators
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valerie uvin, md
Role: PRINCIPAL_INVESTIGATOR
UZ Brussels
Locations
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UZ Brussel
Brussels, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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TgABstudy Brussels
Identifier Type: -
Identifier Source: org_study_id
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