Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome

NCT ID: NCT06179368

Last Updated: 2024-01-16

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-01-01
• Study Completion Date: 2024-05-01

Brief Summary

Liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to triiodothyronine (T3) by Type 1 deiodinase.

Detailed Description

In clinical terms, cirrhosis is described as are either "compensated" or "decompensated." Decompensation means cirrhosis complicated by one or more of the following features: jaundice, ascites, hepatic encephalopathy (HE), or bleeding varices. Ascites is the usual first sign. Hepatorenal syndrome, hyponatremia, and spontaneous bacterial peritonitis are also features of decompensation, but in these patients, ascites invariably occurs first. Compensated cirrhotic patients have none of these features.

The liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to T3 by Type 1 deiodinase.

T4 and T3 regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulate hepatic function. The liver metabolizes the THS and regulates their systemic endocrine effects. Thyroid diseases may perturb liver function; liver disease modulates thyroid hormone metabolism; and a variety of systemic diseases affect both the organs.

Conditions

Hepatic Encephalopathy; Hepatic Impairment; Hypothyroidism; Hepatic Failure

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Hypothroid group

throid fuction will be evaluated on admission of hepatic failure patients, and the hypothroid patients will be enroled in this group.

hypothroidism

Intervention Type: DIAGNOSTIC_TEST

throid fuction will be evaluated on admission of hepatic failure patients, and the hypothyroid patients will be enroled in this group.

Euthroid group

throid fuction will be evaluated on admission of hepatic failure patients, and the euothroid patients will be enroled in this group.

euothyroid

Intervention Type: DIAGNOSTIC_TEST

throid fuction will be evaluated on admission of hepatic failure patients, and the euothyroid patients will be enroled in this group.

Interventions

hypothroidism

throid fuction will be evaluated on admission of hepatic failure patients, and the hypothyroid patients will be enroled in this group.

Intervention Type: DIAGNOSTIC_TEST

euothyroid

throid fuction will be evaluated on admission of hepatic failure patients, and the euothyroid patients will be enroled in this group.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• hepatic fauiure patients

Exclusion Criteria

• hypethyroid patients

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Emad Zarief , MD

professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Emad Zarief Kamel Said

Asyut, , Egypt

Site Status: RECRUITING

Countries

Egypt

Facility Contacts

Emad Z Kamel, M.D.

Role: primary

emadzarief@yahoo.com

+201007046058

References

Punekar P, Sharma AK, Jain A. A Study of Thyroid Dysfunction in Cirrhosis of Liver and Correlation with Severity of Liver Disease. Indian J Endocrinol Metab. 2018 Sep-Oct;22(5):645-650. doi: 10.4103/ijem.IJEM_25_18.

Reference Type: BACKGROUND

PMID: 30294575 (View on PubMed)

McCormick PA. Sherlock's Diseases of the Liver and Biliary System Textbook. Hepatic Cirrhosis. In: Dooley JS, Lok AS, Burroughs AK, Heathcote EJ, editors. 12th ed. Ch. 7. UK: Wiley-Blackwell, A John Wiley and Sons, Ltd; 2011. pp. 103-8.

Reference Type: BACKGROUND

Other Identifiers

IRB121223

Identifier Type: -

Identifier Source: org_study_id