Hypothyroidism in Patients With Type 2 Diabetes With Early Diabetic Nephropathy

NCT ID: NCT03178253

Last Updated: 2017-06-07

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-06-30
• Study Completion Date: 2018-06-30

Brief Summary

Diabetes Mellitus is the most common disorder seen. The impact of this disease on the quality of life, and on morbidity and mortality through the complications that affect the small and large vessels resulting in retinopathy, nephropathy, neuropathy, and ischemic heart disease has been emphasized by the findings of the national commission (USA) on diabetes .

So, there was curiosity to understand and learn the association of this disorder with another common endocrine gland function that is thyroid gland . The association between these two disorders has long been recognized although the prevalence of thyroid dysfunction in diabetic population varies widely between studies. With insulin and thyroid hormone being intimately involved in cellular metabolism and thus excess or deficit of these hormones result in functional derangement of the other.

Detailed Description

Diabetic patients have higher prevalence of thyroid disorder when compared with the normal population. Diabetic women are more frequently affected than men and hypothyroidism is more common than thyrotoxicosis .

Sub-clinical hypothyroidism is an independent risk factor for development of diabetic nephropathy. Severe hypothyroidism (biochemically) may be completely asymptomatic. Though our patient had throid stimulating hormone level more than 100 mIU/L, he did not have any symptoms of hypothyroidism.so diagnosis of hypothyroidism depends on laboratory parameters rather than clinical findings Recognition and treatment of hypothyroidism in diabetic patients will benefit glycemic control and improve general well-being ). Diabetic nephropathy, a major micro-vascular complication of type 2 diabetes mellitus, is an important cause of chronic kidney disease. It results from interactions between hemodynamic and metabolic factors .

Conditions

Hypothyroidism in Diabetes

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

3

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• All patients with Type 2 diabetes mellitus and with diabetic nephropathy.
• All diabetics irrespective of glucose control.
• All diabetics irrespective of treatment (oral hypoglycemic drugs/insulin)

Exclusion Criteria

• 1) Type 1 diabetes mellitus 2) Patients with:

• Gestational diabetes mellitus.
• Pancreatitis.
• Steroid induced Diabetes.
• hepatobiliary disease
• on systemic drug therapy such glucocorticoids and oral contraceptives.

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

maria hamdy

Assiut University

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Maria Hamdy

Asyut, , Egypt

Countries

Egypt

Other Identifiers

assuit1991

Identifier Type: -

Identifier Source: org_study_id