Iodine Nutrition Status and Clinical Characteristics of Thyroid Cancer

NCT ID: NCT06623500

Last Updated: 2024-10-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-01

Study Completion Date

2026-12-31

Brief Summary

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The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019,and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.

Detailed Description

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Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.

Conditions

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Thyroid Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Excessive iodine group

Residents with thyroid cancer who have lived in high iodine areas for a long time (5 years or more). According to the report of Shandong Institute of Endemic Disease Prevention and Control, three sub centers were selected in Excessive iodine group (Jining/Liaocheng/Heze).

Iodine excess

Intervention Type DIETARY_SUPPLEMENT

Iodine excess areas: water iodine ≥100μg/L; or urinary iodine concentration (median urinary iodine levels in children aged 8-10 years old)≥300μg/L

Suitable iodine group

Residents with thyroid cancer who have lived in suitable iodine areas for a long time (5 years or more). According to the report of Shandong Institute of Endemic Disease Prevention and Control, three sub centers were selected in suitable iodine (Jinan/Shenyang/Haerbin) areas.

Iodine suitable

Intervention Type DIETARY_SUPPLEMENT

Iodine suitable areas:water iodine ≥40μg/L and ≤100μg/L; or urinary iodine concentration(median urinary iodine levels in children aged 8-10 years old) 100-199μg/L.

Interventions

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Iodine excess

Iodine excess areas: water iodine ≥100μg/L; or urinary iodine concentration (median urinary iodine levels in children aged 8-10 years old)≥300μg/L

Intervention Type DIETARY_SUPPLEMENT

Iodine suitable

Iodine suitable areas:water iodine ≥40μg/L and ≤100μg/L; or urinary iodine concentration(median urinary iodine levels in children aged 8-10 years old) 100-199μg/L.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

1. Age range: 18\~65 years old, gender not limited;
2. Living in the selected region for at least 5 years;
3. Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer;
4. The clinical data (general information、surgical scope 、pathological report、utrasonic report, etc )of the case is complete.

Exclusion Criteria

1. Diagnosed as other types of cancer or thyroid metastatic cancer;
2. There are serious comorbidities such as heart, liver, and kidney diseases present;
3. Unable to follow up on prognostic information.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shandong Provincial Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Hai-qing Zhang

Chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Shandong Provincial Hospital

Jinan, Shandong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Qingling Guo

Role: CONTACT

+86 0531-68776375

Facility Contacts

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Qingling Guo, doctor

Role: primary

13026575201

Haiqing Zhang, doctor

Role: backup

(86)15168888303

Other Identifiers

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ShandongPH 20240902

Identifier Type: -

Identifier Source: org_study_id

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