Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer
NCT ID: NCT01744769
Last Updated: 2012-12-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
80 participants
OBSERVATIONAL
2012-07-31
2013-05-31
Brief Summary
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2. Because the function of thyroid hormone is closely linked with lipid and glucose metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy may induce the changes of metabolic parameters.
3. We investigate the effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer.
Detailed Description
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2. Measurements
1. Measurement of metabolic and cardiovascular parameters
* glucose profiles : HbA1c, fasting glucose level
* lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride
* adipocytokines : retinol binding protein(RBP)
* 4, leptin, resistin, adiponectin
* markers of endothelial and cardiac function : high-sensitivity C-reactive protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)
* bone turnover markers : CTX, bone ALP
2. Scoring of symptoms and signs of hypothyroidism (Zulewski score)
* symptoms
* physical signs
Conditions
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Keywords
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Hypothyroidism for RAI
The group of patients who experience hypothyroidism after thyroid hormone withdrawal for radioactive iodine(RAI) therapy
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* age over 18
Exclusion Criteria
* infection
* inflammation
* autoimmune disease
* other chronic disease
18 Years
80 Years
ALL
No
Sponsors
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Konkuk University Medical Center
OTHER
Responsible Party
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Suk Kyeong Kim
Associate professor
Principal Investigators
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Suk Kyeong Kim, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Konkuk University Medical Center
Locations
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Konkuk University Medical Center
Seoul, , South Korea
Countries
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Central Contacts
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Facility Contacts
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Jee Hyun An
Role: primary
Other Identifiers
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KUH1010379
Identifier Type: -
Identifier Source: org_study_id