Renal Tracer Elimination in Thyroid Cancer Patients Treated With 131-Iodine

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

83 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2022-12-31

Brief Summary

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Correlation analysis between estimated renal function and biological half life of 131-I during radioiodine treatment of patients with differentiated thyroid cancer.

Detailed Description

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131-I during radioiodine treatment of patients with differentiated thyroid cancer is mainly renally excreted. It is advised in the clinical guidelines that serum creatinine should be determined before applying 131-I and if necessary the administered dose should be reduced. Nevertheless no guideline gives advice in what extent the dose should be decreased. The adjustment is at the discretion of the attending physician.

Aim of this prospective study is to correlate the biological half life of 131-I with the renal function to give objective recommendations concerning the reduction of the applied dose in patients with limited renal function.

Conditions

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Thyroid Carcinoma

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients with differentiated thyroid carcinoma
* stationary for treatment or diagnostic with radioiodine
* state after thyroidectomy
* written consent of the patient
* minimum age 18 years

Exclusion Criteria

* no written consent of the patient
* patients with large residual thyroid tissue (iodine uptake \> 10%)
* children under 18 years of age
* inclusion in concurrent interventional studies
* patients without TSH-stimulation by rhTSH

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Martin Freesmeyer, Dr. med.

Role: PRINCIPAL_INVESTIGATOR

Study Principal Investigator

Locations

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University Hospital Jena

Jena, Thuringia, Germany

Site Status

Countries

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Germany

Other Identifiers

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I-131-07/2015

Identifier Type: -

Identifier Source: org_study_id