Research on Association Between Selenium Deficiencies and Change of Thyroid Function

NCT ID: NCT03448588

Last Updated: 2018-05-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2019-04-01

Brief Summary

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As one of the essential micronutrients, selenium has important biological functions. However, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. Previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( T4) to triiodothyronine (T3). A case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated T4 or T4/T3, which may provide more clues for establishing effective selenium assesment methods.

Detailed Description

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Conditions

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Selenium Deficiency

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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group with normal T4 level or T4/T3

participants with T4 within 4.3-12.5ug/dl and ratio of T4/T3(T4(ug/dl)/T3 (ng/ml)) ≤7.52, which are considered to be normal T4 level and T4/T3.

detection of serum selenium

Intervention Type DIAGNOSTIC_TEST

For this case-control study, no intervention will be administered to participants, only serum sample will be collected for selenium assessment

group with elevated T4 level or T4/T3

participants with T4 more than 12.5ug/dl and ratio of T4/T3(T4(ug/dl)/T3 (ng/ml)) \> 7.52, which are considered to be elevated T4 level and T4/T3.

detection of serum selenium

Intervention Type DIAGNOSTIC_TEST

For this case-control study, no intervention will be administered to participants, only serum sample will be collected for selenium assessment

Interventions

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detection of serum selenium

For this case-control study, no intervention will be administered to participants, only serum sample will be collected for selenium assessment

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* with normal free triiodothyronine( FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH).
* without thyroid hormone replacement therapy
* without medical history of thyroid surgery
* without iodine radiotherapy;

Exclusion Criteria

* acute critical illness in the latest 1 year;
* weight fluctuation by more than 5% in the latest 3 months;
* eating disorders
* neuropsychological disorders
* allergy to corn or yeast
* fail to give informed consents.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Liuyanping

Dietitian

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yanping Liu

Role: CONTACT

+861069159088

Facility Contacts

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yanping liu, master

Role: primary

861069159081

Other Identifiers

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Liuyanping3

Identifier Type: -

Identifier Source: org_study_id

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