Cardiovascular and Cerebrovascular Control in Healthy Subjects

NCT ID: NCT05706532

Last Updated: 2025-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-29

Study Completion Date

2027-10-31

Brief Summary

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The aim of the study is to evaluate autonomic function and cerebrovascular control in 60 healthy subjects by means of noninvasive analysis of time series variability.

To this extent, heart period, systolic and mean arterial blood pressure, cerebral blood velocity, peripheral resistances, respiration will be recorded from subjects during an orthostatic challenge.

The interactions between autonomic cardiovascular function, cerebrovascular and peripheral control will be evaluated exploiting the most advanced signal processing techniques.

Detailed Description

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Conditions

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Healthy Autonomic Nervous System Cerebral Autoregulation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy

60 healthy subjects; age \>18; sinus rhythm; absence of autonomic diseases or dysfunctions.

active standing

Intervention Type DIAGNOSTIC_TEST

Data are acquired with patients resting in supine position for 10 minutes and for 10 minutes during active standing

Interventions

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active standing

Data are acquired with patients resting in supine position for 10 minutes and for 10 minutes during active standing

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* age \>18
* sinus rhythm
* informed consent signed

Exclusion Criteria

* age \<18
* presence of autonomic nervous system diseases or dysfunctions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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IRCCS Policlinico S. Donato

OTHER

Sponsor Role lead

Responsible Party

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Vlasta Bari

Assistant Professor, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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IRCCS Policlinico San Donato

San Donato Milanese, Milan, Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Vlasta Bari, PhD

Role: CONTACT

+390252774381

Facility Contacts

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Vlasta Bari, PhD

Role: primary

+390252774381

Other Identifiers

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CardioSan

Identifier Type: -

Identifier Source: org_study_id

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