Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
EARLY_PHASE1
64 participants
INTERVENTIONAL
2024-09-20
2028-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Women
Women will be 18-70 years of age
Norepinephrine
Infused intra-arterially in a dose-response fashion
Isoproterenol
Infused intra-arterially in a dose-response fashion
Acetylcholine
Infused intra-arterially in a dose-response fashion
Nitroprusside
Infused intra-arterially in a dose-response fashion
Estrogen
Infused intra-arterially
Interventions
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Norepinephrine
Infused intra-arterially in a dose-response fashion
Isoproterenol
Infused intra-arterially in a dose-response fashion
Acetylcholine
Infused intra-arterially in a dose-response fashion
Nitroprusside
Infused intra-arterially in a dose-response fashion
Estrogen
Infused intra-arterially
Eligibility Criteria
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Inclusion Criteria
* 18-70 years of age
Exclusion Criteria
* Pregnancy, breastfeeding
* Body mass index ≥30 kg/m2
* Taking medications known to affect metabolic, autonomic, and/or respiratory function
* Oral hormonal contraception in last 6 month
* History of hormone replacement therapy
* History of hyster- or oophor-ectomy
* Current smoking/Nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Chronic disease
* Blood pressure ≥140/90 mmHg
* Communication barriers
18 Years
70 Years
FEMALE
Yes
Sponsors
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University of Missouri-Columbia
OTHER
American Heart Association (AHA)
UNKNOWN
Responsible Party
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Jacqueline K Limberg, PhD
Associate Professor
Locations
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University of Missouri-Columbia
Columbia, Missouri, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2109189
Identifier Type: -
Identifier Source: org_study_id
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