Exercise Improve Sympathetic Modulation in Chronic Heart Failure Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-08-31

Study Completion Date

2014-07-31

Brief Summary

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The purpose of this study is to verify the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure.

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Detailed Description

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Retrospective study. Patients were recruited by database from Rehabilitation Unit of Cardiovascular Rehabilitation and Exercise Physiology of the Heart Institute (InCor). The aim of this study is to assess the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure. The investigators studied twenty-six chronic heart failure outpatients, age 30 to 70 years, functional class II to III of New York Heart Association, left ventricular ejection fraction (LVEF) ≤40% and peak oxygen uptake (VO2) ≤20. The exclusion criteria were recent myocardial infarction or unstable angina (\<3 months), heart failure duration (\<3 months), permanent pacemaker dependence, atrial fibrillation, skeletal muscle abnormality (e.g., arthritis) and participation in a regular exercise program. They were assigned to 2 groups: Untrained (n=13) and trained (n=13).

Conditions

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Chronic Heart Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

SINGLE

Participants

Study Groups

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exercise training

We studied twenty-six chronic heart failure outpatients and they were assigned to 2 groups: Untrained (n=13) and trained (n=13).

Group Type EXPERIMENTAL

exercise training

Intervention Type OTHER

exercise training

Interventions

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exercise training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with chronic heart failure
* Age 30 to 70 years
* Functional class II to III of New York Heart Association
* Left ventricular ejection fraction (LVEF) ≤40%
* Peak oxygen uptake (VO2) ≤20

Exclusion Criteria

* Recent myocardial infarction or unstable angina (\<3 months)
* heart failure duration (\<3 months)
* Permanent pacemaker dependence
* Atrial fibrillation
* Skeletal muscle abnormality (e.g., arthritis)
* Participation in a regular exercise program

Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No