Physiological Assessment of the Endothelium - Circadian Rhythm and Role of the Sympathetic Nervous System
NCT ID: NCT01713374
Last Updated: 2015-04-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
40 participants
INTERVENTIONAL
2012-10-31
2014-03-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Further, the investigators plan to study the circadian variability of FMC and FMD. The investigators hypothesize a peak of FMD in the late hours of the day and a peak of FMC in the early hours.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Influence of the Autonomic Nervous System in Response to Exercise in Hypertensive Individuals
NCT04371757
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
NCT05997732
High Resolution Phenotyping in Healthy Humans
NCT00943774
Exercise Improve Sympathetic Modulation in Chronic Heart Failure Patients
NCT02219451
Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart
NCT01798992
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Myogenic activation
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of myogenic activation
Myogenic activation
A pneumatic cuff will be inflated to suprasystolic pressure around both thighs and the subjects will be asked to perform plantar flexion exercises.
Cold pressure test
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of cold pressure test
Cold pressure test
A hand will be placed in ice-cold water.
mental stress
Subjects will undergo endothelial function assessment at rest and, after a 45 minutes pause, 1 minute after begin of mental stress
Mental stress
Subjects will be asked to perform complex mathematic operations at a very fast pace
Control
Control visit - no intervention performed - subjects will undergo endothelial function measurement twice at a distance of 45 minutes
no intervention
control visit
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Mental stress
Subjects will be asked to perform complex mathematic operations at a very fast pace
no intervention
control visit
Myogenic activation
A pneumatic cuff will be inflated to suprasystolic pressure around both thighs and the subjects will be asked to perform plantar flexion exercises.
Cold pressure test
A hand will be placed in ice-cold water.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
Exclusion Criteria
18 Years
40 Years
MALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Johannes Gutenberg University Mainz
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Tommaso Gori
Professor
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Tommaso Gori, MD PhD
Role: PRINCIPAL_INVESTIGATOR
University Medical Center Mainz
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University Medical Center Mainz
Mainz, Rhineland-Palatinate, Germany
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
PAN-1
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.