Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva
NCT ID: NCT04918563
Last Updated: 2021-06-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2020-09-15
2021-05-15
Brief Summary
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Detailed Description
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For blood flow measurement Laser Spackle Contrast Imaging is a reliable tool. It has good reproducibility, it doesn't get in touch with the measured surface, it's easy to use and it can measure on a bigger surface in same time.
Two wells were fabricated on the labial surface of the right lateral incisor (test tooth) and on the labial surface of the left central incisor (control tooth). These wells are opened towards the high-prermeability gingival sulcus, so the dropped solutions nitroglycerine vs physiological saline or nitroglycerine vs physiological saline can esasily penetrate to the gingival tissues. After applying the solutions, the blood flow was monitored fot 15 minutes.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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nitroglycerin
NO donor (Nitropohl) vs pgysiological saline
1mg/ml nitorhlycerin
Nitroglycerin
Vasodilatator solution is dropped on the labial surface on the lateral incisor, so it can penetrate through the sulcus.
acethylcholine
10 mg/ml acetylcholine vs physiological saline
Acetylcholine
Vasodilatator solution is dropped on the labial surface on the lateral incisor, so it can penetrate through the sulcus.
Interventions
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Nitroglycerin
Vasodilatator solution is dropped on the labial surface on the lateral incisor, so it can penetrate through the sulcus.
Acetylcholine
Vasodilatator solution is dropped on the labial surface on the lateral incisor, so it can penetrate through the sulcus.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* minimum 5 mm keratinized gingiva at the upper front teeth
* good oral hygiene
Exclusion Criteria
* smoking
* medication
* insufficient marginal integrity
* periodontitis
* caries
20 Years
30 Years
ALL
Yes
Sponsors
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Semmelweis University
OTHER
Responsible Party
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Dr. Vag Janos
associate professor
Locations
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Semmelweis University, Department of Conservative Dentistry
Budapest, , Hungary
Countries
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References
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Vag J, Nagy TL, Mikecs B. Sex-related differences in endothelium-dependent vasodilation of human gingiva. BMC Oral Health. 2022 May 13;22(1):177. doi: 10.1186/s12903-022-02186-2.
Other Identifiers
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1/2020
Identifier Type: -
Identifier Source: org_study_id
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