Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

44 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-01

Study Completion Date

2022-03-01

Brief Summary

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This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery. Participants will be administered a topical sublingual nitroglycerin solution and assessed for changes microcirculatory blood flow using incident dark field microscopy.

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Detailed Description

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Conditions

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Circulatory Shock Cardiovascular Shock

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Topical nitroglycerin

A topical nitroglycerin solution will be applied to the area of interest

Nitroglycerin Topical Product

Intervention Type DRUG

Topical nitroglycerin solution

Interventions

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Nitroglycerin Topical Product

Topical nitroglycerin solution

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult patients receiving elective CABG or valvular surgery requiring cardiopulmonary bypass
* Receiving postoperative catecholamine therapy to maintain a MAP \> 65mmHg, cardiac index \> 2 despite initial fluid resuscitation
* Invasive hemodynamic monitoring

Exclusion Criteria

* Surgical hemorrhage
* Unable to tolerate sublingual microcirculatory flow imaging
* Known intolerance or allergy to nitroglycerin
* Inadequate microcirculation imaging (based on Massey Score)

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No