Blockade of Vascular Potassium Channels During Human Endotoxemia
NCT ID: NCT00185003
Last Updated: 2008-10-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
36 participants
INTERVENTIONAL
2003-01-31
2005-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Interventions
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endotoxin
Potassium channel blockers: TEA, Quinin, Tolbutamide
L-NMMA
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
35 Years
ALL
Yes
Sponsors
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ZonMw: The Netherlands Organisation for Health Research and Development
OTHER
Radboud University Medical Center
OTHER
Principal Investigators
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Peter Pickkers, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Radboud University Medical Center
References
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Pickkers P, Dorresteijn MJ, Bouw MP, van der Hoeven JG, Smits P. In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia. Circulation. 2006 Aug 1;114(5):414-21. doi: 10.1161/CIRCULATIONAHA.105.590232. Epub 2006 Jul 24.
Other Identifiers
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ZONMW grant 907-00-056
Identifier Type: -
Identifier Source: secondary_id
PP02
Identifier Type: -
Identifier Source: org_study_id
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