Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2008-03-31

Brief Summary

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A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

Detailed Description

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Conditions

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Hypertension

Keywords

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hypertension statin sympathetic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Interventions

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atorvastatin 80 mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* (Known) hypertension
* stable drug therapy for at least 2 months
* age 18-70 jaar
* BMI 18-35 kg/m2
* Sinusrhythm

Exclusion Criteria

* Recent cardiovascular event \<6 mnd
* Plasma Creatinin:
* female: \>120 mmol/L
* male: \>133 mmol/L
* use of:
* tricyclic antidepressants
* alpha-1 -and/or alpha-2 blockers
* disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
* Albuminuria \>300 mg/dag

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Cees J Tack, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Radboud University Medical Center

Locations

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Radboud University Medical Center Nijmegen

Nijmegen, , Netherlands

Site Status

Countries

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Netherlands

References

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Gomes ME, Tack CJ, Verheugt FW, Smits P, Lenders JW. Sympathoinhibition by atorvastatin in hypertensive patients. Circ J. 2010 Nov;74(12):2622-6. doi: 10.1253/circj.cj-10-0427. Epub 2010 Oct 9.

Reference Type DERIVED

PMID: 20953062 (View on PubMed)

Other Identifiers

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HTSTAT

Identifier Type: -

Identifier Source: org_study_id