Importance of Liver Innervation for the Osmopressor Response in Humans
NCT ID: NCT01237431
Last Updated: 2011-02-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2009-11-30
2011-01-31
Brief Summary
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The investigators believe that the response to water may be mediated through sympathetic activation elicited by osmosensitve spinal afferents in the liver. Therefore, the investigators want to test water in liver transplant patients who have a denervated liver. Kidney transplant patients serve as control subjects. The investigators hypothesize that the increase in norepinephrine after water drinking is blunted in liver transplant recipients.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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liver transplanted patients
Target group to confirm the hypothesis. Transplantation has to be between 6 an 24 Month before participation.
500ml water intake
subjects have to ingest 500ml water within 5 minutes after resting 30 minutes in supine position
kidney transplanted patients
Control group, age, gender and medication matched. Transplantation has to be between 6 an 24 Month before participation.
500ml water intake
subjects have to ingest 500ml water within 5 minutes after resting 30 minutes in supine position
Interventions
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500ml water intake
subjects have to ingest 500ml water within 5 minutes after resting 30 minutes in supine position
Eligibility Criteria
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Inclusion Criteria
* age 18 to 60
* written informed consent
* ability to understand the oral and written information
Exclusion Criteria
* transplantation of another organ
* chronic heart or vascular disease
* known alcohol or drug abuse
* psychiatric diseases (e.g. chronic depression, schizophrenia, drug addiction)
18 Years
60 Years
ALL
No
Sponsors
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Hannover Medical School
OTHER
Responsible Party
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Medical School Hannover
Locations
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Hannover Medical School
Hanover, NDS, Germany
Countries
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References
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May M, Gueler F, Barg-Hock H, Heiringhoff KH, Engeli S, Heusser K, Diedrich A, Brandt A, Strassburg CP, Tank J, Sweep FC, Jordan J. Liver afferents contribute to water drinking-induced sympathetic activation in human subjects: a clinical trial. PLoS One. 2011;6(10):e25898. doi: 10.1371/journal.pone.0025898. Epub 2011 Oct 7.
Other Identifiers
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D-MHH-Hep_Reflex-EK5413
Identifier Type: -
Identifier Source: org_study_id
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