Water and the Gastropressor Response - Tachyphylaxis

NCT ID: NCT00580996

Last Updated: 2025-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-07-31

Study Completion Date

2029-12-31

Brief Summary

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We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.

Detailed Description

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We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.

Conditions

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Orthostatic Hypotension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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1

16 oz water in AM

Group Type EXPERIMENTAL

water high dose

Intervention Type OTHER

water 16 oz PO x 1

2

water 1 oz in AM

Group Type ACTIVE_COMPARATOR

water tiny dose

Intervention Type OTHER

water 1 oz PO x 1

Interventions

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water high dose

water 16 oz PO x 1

Intervention Type OTHER

water tiny dose

water 1 oz PO x 1

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* orthostatic hypotension (fall in BP\>20/10 mmHg)
* pressor response to water in other studies
* Age 18-80 years

Exclusion Criteria

* pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Satish R. Raj

OTHER

Sponsor Role lead

Responsible Party

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Satish R. Raj

Assistant Professor of Medicine & Pharmacology

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Satish R Raj, MD MSCI

Role: PRINCIPAL_INVESTIGATOR

Vanderbilt University Medical Center

Locations

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Vanderbilt University

Nashville, Tennessee, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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Vanderbilt Discovery

Identifier Type: OTHER

Identifier Source: secondary_id

060547

Identifier Type: -

Identifier Source: org_study_id

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