Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2028-06-30

Brief Summary

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The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).

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Detailed Description

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Conditions

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Postural Tachycardia Syndrome

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Exercise Post Saline

Saline infusion 1L hours before exercise test

Group Type EXPERIMENTAL

Saline

Intervention Type DRUG

IV Normal Saline infused over 30-60 minutes given 3-6 hours PRIOR to exercise study

Placebo

Placebo given prior to exercise test

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Placebo x1 lactose tablet

Interventions

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Saline

IV Normal Saline infused over 30-60 minutes given 3-6 hours PRIOR to exercise study

Intervention Type DRUG

Placebo

Placebo x1 lactose tablet

Intervention Type OTHER

Other Intervention Names

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Normal Saline 0.9% saline

Eligibility Criteria

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Inclusion Criteria

* Meet diagnostic criteria of Postural Tachycardia Syndrome (POTS) 28
* Age between 18-65 years
* Male and female are eligible (although the majority of POTS patients are female).
* Able and willing to provide informed consent

Exclusion Criteria

* Presence of medical conditions that can explain postural tachycardia (e.g., acute dehydration, medications)
* Pregnancy
* Other factors which in the investigator's opinion would prevent the subject from completing the protocol.
* Patients who are bedridden or chair-ridden

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No