Comparison of Apexification and Regenerative Endodontic Therapy: a Retrospective Study

NCT ID: NCT05213026

Last Updated: 2024-03-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-10-07
• Study Completion Date: 2022-01-04

Brief Summary

In this study, the effects of mineral trioxide aggregation (MTA) apexification and regenerative endodontic treatment (RET) methods on periapical healing was compared with fractal analysis (FD) and periapical index (PAI).

Detailed Description

The fractal dimension analysis of each radiograph was performed using the box-counting method proposed by White and Rudolph [1] (Figure 1). All periapical radiographs in high resolution Jpeg format to be included in the study was converted to tagged image file formats (TIFF). Each ROI at 18 x 19 pixels and 2 mm from the radiographic apex was selected, cropped and amplified. "Gaussian Blur" was used to eliminate the brightness changes due to soft tissues and variable bone thicknesses. The resulting image was then be subtracted from the original image. Bone marrow spaces and trabeculae were separated from each other by adding 128 gray values to each pixel location. The fractal dimension was calculated after the binary, etching, dilate, inversion and skeletonization operations were done.

This study was carried out on the radiographic records of patients who applied to Istanbul University Faculty of Dentistry, Department of Pedodontics, who had at least one immature incisor treated with MTA apexification and RET method, and who had at least one-year follow-up radiographs.

Cases in which all endodontic treatments were performed by the same pedodontist (GK) were examined.

Conditions

Regenerative Endodontic; Apexification; Fractals

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

Apexification

Apexification treatment was applied by a single operator (GK) in Istanbul University Faculty of Dentistry, Department of Pedodontics,

• Having no systemic or periodontal problems,
• Asymptomatic or diagnosed with apical periodontitis with fistula tract,
• Not having external/internal resorption, fracture, more than one root/canal,
• Root canal filling is sufficient for the MTA,
• Root canal filling and coronal restorations were completed in Istanbul University Faculty of Dentistry Department of Pedodontics,
• Cases with periapical radiographs taken before the procedure and at least one year after the procedure was included.

No interventions assigned to this group

Regenerative

Apexification treatment was applied by a single operator (GK) in Istanbul University Faculty of Dentistry, Department of Pedodontics,

• Having no systemic or periodontal problems,
• Asymptomatic or diagnosed with apical periodontitis with fistula tract,
• Not having external/internal resorption, fracture, more than one root/canal,
• Root canal filling and coronal restorations were completed in Istanbul University Faculty of Dentistry Department of Pedodontics,
• Cases with periapical radiographs taken before the procedure and at least one year after the procedure was included.

Regenerative endodontics

Intervention Type: PROCEDURE

Regenerative endodontic procedure with 3 Mix-MP

Interventions

Regenerative endodontics

Regenerative endodontic procedure with 3 Mix-MP

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Apexification treatment was applied by a single operator (GK) in Istanbul University Faculty of Dentistry, Department of Pedodontics,

• Having no systemic or periodontal problems,
• Asymptomatic or diagnosed with apical periodontitis with fistula tract,
• Not having external/internal resorption, fracture, more than one root/canal,
• Root canal filling is sufficient for the MTA group,
• Root canal filling and coronal restorations were completed in Istanbul University Faculty of Dentistry Department of Pedodontics,
• Cases with periapical radiographs taken before the procedure and at least one year after the procedure was included.

Exclusion Criteria

• Cases treated by different pediatric dentists,

• Cases in which apexification is performed by different operators,
• Cases with systemic or periodontal disease,
• Cases with external/internal resorption, fracture, more than one root/canal,
• Cases where root canal filling is not sufficient
• Cases in which root canal filling and conoral restorations were completed over 2 years,
• Cases without radiographs taken before or at least one year after the procedure,
• Cases with artifacts in the periapical region on their radiographs

• Minimum Eligible Age: 7 Years
• Maximum Eligible Age: 12 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Istanbul Kent University

OTHER

Sponsor Role: collaborator

Abant Izzet Baysal University

OTHER

Sponsor Role: collaborator

Istanbul University

OTHER

Sponsor Role: lead

Responsible Party

Yelda Kasımoğlu

Assoc. Prof.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Istanbul University, Faculty of Dentistry

Istanbul, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

2019/53

Identifier Type: -

Identifier Source: org_study_id