Comparison of the Genotoxicity of Desflurane and Propofol

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-17

Study Completion Date

2022-03-20

Brief Summary

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The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.

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Detailed Description

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It is expected that DNA damage information provide the possible genotoxic effects of inhalational and intravenous anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed patients.

Conditions

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DNA Damage Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Desflurane Group

Desflurane 1,0 minimum alveolar concentration will be administered during anesthesia maintenance

Group Type EXPERIMENTAL

Anesthetics, General Desflurane Maintenance

Intervention Type DRUG

Comparison of dna damage of desflurane maintenance with propofol maintenance according to comet analysis

Propofol Group

Propofol 6 mg//kg/hour will be administered during anesthesia maintenance

Group Type EXPERIMENTAL

Anesthetics, General Propofol Maintenance

Intervention Type DRUG

Comparison of dna damage of propofol maintenance with desflurane maintenance according to comet analysis

Interventions

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Anesthetics, General Desflurane Maintenance

Comparison of dna damage of desflurane maintenance with propofol maintenance according to comet analysis

Intervention Type DRUG

Anesthetics, General Propofol Maintenance

Comparison of dna damage of propofol maintenance with desflurane maintenance according to comet analysis

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Ability to understand and willingness to sign an informed consent form
2. Elective lumbar spinal surgery that will take at least 120 minutes,
3. American Society of Anesthesiologists (ASA) physical status I and II

Exclusion Criteria

1. Patients with ASA physical status III or IV disease
2. Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders)
3. Smoking or alcohol consumption
4. Recently received radiation, chemotherapy
5. Malignancy
6. Patients who will receive blood transfusion during the operation
7. Users of antioxidant supplements
8. Patients who have received general anesthesia in the last three months
9. Patients with known occupational exposures (operating room personnel, chemical plant worker

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes