Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
40 participants
OBSERVATIONAL
2024-05-23
2024-06-05
Brief Summary
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The two main agents used in maintenance for general anesthesia are inhalation and intravenous anesthetics. Both inhalation anesthesia and TIVA (Total Intravenous Anesthesia) approaches provide general anesthesia suitable for surgical operations. However, the mechanisms of action of these two methods differ and are not fully understood.
The aim of investigators' for this study was to investigate the effect of different anesthetic agents on stress inflammatory response in the preoperative, peroperative and postoperative periods.
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Detailed Description
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The two main agents used in maintenance for general anesthesia are inhalation and intravenous anesthetics. Both inhalation anesthesia and TIVA (Total Intravenous Anesthesia) approaches provide general anesthesia suitable for surgical operations.Previous studies have shown that inhalation agents alter immune processes and are proinflammatory. In contrast, propofol has been shown to suppress tumor growth and has anti-inflammatory and antioxidant activities.
The aim of investigators' for this study was to investigate the effect of different anesthetic agents on stress inflammatory response in the preoperative, peroperative and postoperative periods.
This single-center prospective,observational study was approved by Institutional Ethics Committee (Decision number: 2024/010.99/15, Date: 28/02/2024) and was started to performed in accordance with the Declaration of Helsinki. In this study, 40 patients in the ASA I-II group who will be operated electively for lumbar disc herniation between March and June 2023 in the operating room of the Neurosurgery Department of Kartal Dr Lütfi Kırdar City Hospital will be divided into two groups to be maintained with sevoflurane or propofol by appropriate randomization.
Blood samples collected before surgical intervention (T1), intraoperative 30 minutes (T2) and postoperative 12 hours (T3) will be analyzed and parameters that may be related to stress inflammatory response such as glucose, WBC, procalcitonin, CRP, erythrocyte sedimentation rate, transferrin, ferritin, albumin, prealbumin will be compared.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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propofol
General anesthesia will maintain with propofol in this group.
taking blood sample
A blood sample will be taken from the patients for 3 times to evaluate the stress inflammatory markers.
sevoflurane
General anesthesia will maintain with sevoflurane in this group.
taking blood sample
A blood sample will be taken from the patients for 3 times to evaluate the stress inflammatory markers.
Interventions
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taking blood sample
A blood sample will be taken from the patients for 3 times to evaluate the stress inflammatory markers.
Eligibility Criteria
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Inclusion Criteria
* Motor deficit
* L4-5, L5-S1 levels disc herniation
* 18-65 years
* ASA I-II
Exclusion Criteria
* Narrow channel
* Trauma
* Infection
* Endocrine disease
18 Years
65 Years
ALL
No
Sponsors
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Dr. Lutfi Kirdar Kartal Training and Research Hospital
OTHER_GOV
Responsible Party
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Merve Bulun Yediyıldız
Anesthesiology Specialist, MD
Locations
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University of Health Science, Kartal Dr Lutfi Kırdar Training and Researh Hospital
Istanbul, , Turkey (Türkiye)
Countries
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References
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Yediyildiz MB, Durmus I, Ak HY, Taskin K, Ceylan MAD, Yuce Y, Cevik B, Aydogmus E. Comparison of inhalation and total intravenous anesthesia on inflammatory markers in microdiscectomy: a double-blind study. BMC Anesthesiol. 2025 May 10;25(1):238. doi: 10.1186/s12871-025-03119-6.
Other Identifiers
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010.99/15
Identifier Type: -
Identifier Source: org_study_id
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